2021
DOI: 10.21037/tlcr-20-1134
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: In this review, we aim to collect and discuss available data about the role and composition of tumor microenvironment (TME) in oligometastatic (OMD) and oligoprogressive (OPD) non-small cell lung cancer (NSCLC). Furthermore, we aim to summarize the ongoing clinical trials evaluating as exploratory objective the TME composition, through tissue and/or blood samples, in order to clarify whether TME and its components could explain, at least partially, the oligometastatic/oligoprogressive process and could unravel… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

0
9
0

Year Published

2021
2021
2024
2024

Publication Types

Select...
6

Relationship

0
6

Authors

Journals

citations
Cited by 11 publications
(9 citation statements)
references
References 115 publications
(119 reference statements)
0
9
0
Order By: Relevance
“…To date, only little evidence is present on the association between the histological subtypes, mutational status, or tumor microenvironment and the prognosis of patients with oligometastatic NSCLC undergoing LAT [ 61 ]. In the meta-analysis of Ashworth et al, adenocarcinoma histology was associated with an improved OS [ 13 ].…”
Section: Patient Selection Criteria For Local Aggressive Therapymentioning
confidence: 99%
See 3 more Smart Citations
“…To date, only little evidence is present on the association between the histological subtypes, mutational status, or tumor microenvironment and the prognosis of patients with oligometastatic NSCLC undergoing LAT [ 61 ]. In the meta-analysis of Ashworth et al, adenocarcinoma histology was associated with an improved OS [ 13 ].…”
Section: Patient Selection Criteria For Local Aggressive Therapymentioning
confidence: 99%
“…In a systematic review by Bertolaccini et al, a histologic grading of G1/G2 was found to be a positive prognostic factor for OS [ 62 ]. While the molecular mechanisms and the effect of the tumor microenvironment on cancer progression and metastasization have been extensively investigated in model systems, translational studies evaluating the real impact of the tumor microenvironment on treatment success in oligometastatic disease are lacking [ 61 ]. However, most of the currently ongoing trials on LAT in oligometastatic NSCLC include a collection of tissue for secondary analyses.…”
Section: Patient Selection Criteria For Local Aggressive Therapymentioning
confidence: 99%
See 2 more Smart Citations
“…The tumor microenvironment is a complex and heterogeneous ecological environment, consisting of cancer cells, stromal cells, blood vessels, and extracellular matrix, which affect cell proliferation, mutation, invasion, metastasis, and drug treatment efficacy. [6][7][8] Several studies have found significant heterogeneity between primary NSCLC and its paired metastatic microenvironment, such as the immune environment, angiogenesis, and biomarkers. 9-13 Moreover, different gene expression profiles were noted between primary lesions and paired metastases in patients with NSCLC, such as EGFR, KRAS, and other molecular expressions, including VEGFR, ERCC1, and KI67.…”
Section: Introductionmentioning
confidence: 99%