A nanostructured SAW chip-based biosensor detecting cancer cells

Bröker, Patrick; Lücke, Klaus; Perpeet, M.; Gronewold, Thomas M. A.

doi:10.1016/j.snb.2011.11.022

Cited by 30 publications

(23 citation statements)

References 31 publications

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“…Gold nanoparticles can be functionalized on a nanostructured chip surface enabling binding with CTCs and enumeration of CTCs without labeling . For instance, a gold nanostructured chip was fabricated from the SiO 2 surface of a chip using the wet‐lithographic method and functionalized to capture CTCs via coating and activation of a self‐assembled monolayer of 11‐mercaptoundecanoic acid, followed by antibody immobilization . The amount of antibodies bound to the gold nanostructured surface and biomolecular interaction processes on the sensor chip surface could be quantified in real time by measuring signal changes in phase shift and amplitude of the electroacoustic resonance.…”

Section: Nanotechnology Used In Emerging Ctc Detection Platformsmentioning

confidence: 99%

“…The amount of antibodies bound to the gold nanostructured surface and biomolecular interaction processes on the sensor chip surface could be quantified in real time by measuring signal changes in phase shift and amplitude of the electroacoustic resonance. Using a relatively low concentration of antibodies, the gold nanostructured chip successfully detected CD4‐positive human lymphoblastic leukemia cell JEG‐3 and human placental choriocarcinoma cell MOLT‐17, whereas a reference surface covered with human immunoglobulins did not …”

Section: Nanotechnology Used In Emerging Ctc Detection Platformsmentioning

confidence: 99%

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Recent advances in nanotechnology‐based detection and separation of circulating tumor cells

Myung

Tam

Park

et al. 2015

WIREs Nanomed Nanobiotechnol

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Although circulating tumor cells (CTCs) in blood have been widely investigated as a potential biomarker for diagnosis and prognosis of metastatic cancer, their inherent rarity and heterogeneity bring tremendous challenges to develop a CTC detection method with clinically significant specificity and sensitivity. With advances in nanotechnology, a series of new methods that are highly promising have emerged to enable or enhance detection and separation of CTCs from blood. In this review, we systematically categorize nanomaterials, such as gold nanoparticles, magnetic nanoparticles, quantum dots, graphenes/graphene oxides, and dendrimers and stimuli-responsive polymers, used in the newly developed CTC detection methods. This will provide a comprehensive overview of recent advances in the CTC detection achieved through application of nanotechnology as well as the challenges that these existing technologies must overcome to be directly impactful on human health.

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Section: Nanotechnology Used In Emerging Ctc Detection Platformsmentioning

confidence: 99%

Section: Nanotechnology Used In Emerging Ctc Detection Platformsmentioning

confidence: 99%

Recent advances in nanotechnology‐based detection and separation of circulating tumor cells

Myung

Tam

Park

et al. 2015

WIREs Nanomed Nanobiotechnol

View full text Add to dashboard Cite

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“…Since the detection is made in liquid medium thus, for typical bio-sensing applications [ 145 ], Love Wave and (SH-SAW) devices are suitable choices. Bröker et al [ 146 ] immobilized natural antibodies via a self-assembly process to confine gold nanospots on the SiO 2 surface of a SAW chip. The shift in phase signal that corresponds to mass loadings is thus taken as the sensor response.…”

Section: Chemical Recognition Layersmentioning

confidence: 99%

Surface Acoustic Wave (SAW) for Chemical Sensing Applications of Recognition Layers

Mujahid

Dickert

2017

Sensors

142

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Surface acoustic wave (SAW) resonators represent some of the most prominent acoustic devices for chemical sensing applications. As their frequency ranges from several hundred MHz to GHz, therefore they can record remarkably diminutive frequency shifts resulting from exceptionally small mass loadings. Their miniaturized design, high thermal stability and possibility of wireless integration make these devices highly competitive. Owing to these special characteristics, they are widely accepted as smart transducers that can be combined with a variety of recognition layers based on host-guest interactions, metal oxide coatings, carbon nanotubes, graphene sheets, functional polymers and biological receptors. As a result of this, there is a broad spectrum of SAW sensors, i.e., having sensing applications ranging from small gas molecules to large bio-analytes or even whole cell structures. This review shall cover from the fundamentals to modern design developments in SAW devices with respect to interfacial receptor coatings for exemplary sensor applications. The related problems and their possible solutions shall also be covered, with a focus on emerging trends and future opportunities for making SAW as established sensing technology.

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“…Different cell types including tumor cells were successfully detected with high sensitivity using mass and viscosity changes. Compared with flat gold surface covered with antibodies, cell detection sensitivity was enhanced (gain factor: 100‐fold) by using nanostructured surfaces . Metallic or metallized NMs, such as noble metal NPs have been used for the fabrication of a new type of optical nanobiosensor technique called localized surface plasmon resonance (LSPR) .…”

Section: Self‐assembled Monolayers Of Nanomaterials As Biomaterialsmentioning

confidence: 99%

Self-assembled Monolayers and Nanocomposite Hydrogels of Functional Nanomaterials for Tissue Engineering Applications

2014

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In biotechnology, SAMs and NC hydrogels of functional nanomaterials are of high interest as 2D and 3D cell culture systems, respectively, to mimic natural ECM and to control cell behaviors. Advanced biotechnological approaches often use nanoscale topography together with suitable surface functionalization, as a model of ECM, to control cell behaviors and tissue formation. SAMs of NMs are effective ECM models as 2D surfaces due to their larger nanostructured surface areas which provide higher molecular density by functionalization on a planar substrate than molecular SAMs. Additionally, NC hydrogels, produced by cross-linking of organic polymers with NMs, are excellent candidates as 3D cell culture systems owing to their optical, cell-compatibility and the extraordinary mechanical properties.

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A nanostructured SAW chip-based biosensor detecting cancer cells

Cited by 30 publications

References 31 publications

Recent advances in nanotechnology‐based detection and separation of circulating tumor cells

Recent advances in nanotechnology‐based detection and separation of circulating tumor cells

Surface Acoustic Wave (SAW) for Chemical Sensing Applications of Recognition Layers

Self-assembled Monolayers and Nanocomposite Hydrogels of Functional Nanomaterials for Tissue Engineering Applications

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