A nanosorbent consisting of a magnetic molecularly imprinted polymer and graphene oxide for multi-residue analysis of cephalosporins

Nurrokhimah, Miftah; Nurerk, Piyaluk; Kanatharana, Proespichaya; Bunkoed, Opas

doi:10.1007/s00604-019-3985-5

Cited by 35 publications

(13 citation statements)

References 29 publications

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“…In general, templates can be divided into four groups, namely ions (Cu 2+ , Cd 2+ , and Pb 2+ ), organic molecules (drugs and chemicals), biomacromolecules (albumin and adenosine), and cells (viruses) [ 27 ]. So far, the templates used in MT-MIP have mostly been compounds in the same group [ 32 , 33 , 73 , 74 , 75 ]. The selection of compounds in the same group aims to facilitate the easy selection of functional monomers, crosslinkers, initiators, and porogens because the templates have similar characteristics [ 73 ].…”

Section: Multi-template Strategymentioning

confidence: 99%

“…The selection of compounds in the same group aims to facilitate the easy selection of functional monomers, crosslinkers, initiators, and porogens because the templates have similar characteristics [ 73 ]. Examples of templates that have been used for MT-MIPs are cephalosporin antibiotics (cefoperazone, cefazolin, and cephalexin), non-steroidal anti-inflammatory drugs (NSAIDs; naproxen, ibuprofen, and diclofenac), and sulphonamide antibacterial drugs (sulphanilamide, sulphacetamide, sulphadiazine, sulphathiazole, sulphamerazine, sulphamethizole) [ 32 , 33 , 73 , 75 , 76 , 77 ].…”

Section: Multi-template Strategymentioning

confidence: 99%

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A Review: Using Multiple Templates for Molecular Imprinted Polymer: Is It Good?

et al. 2022

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A multi-template molecularly imprinting polymer (MT-MIP) strategy has been proposed and is increasingly utilised to synthesise MIP with multiple recognition sites in a single polymer using multiple target species as templates. This approach can expand MIP applications for simultaneous recognition and extraction of more than one analyte. The advantages of MT-MIP are simultaneous analyte extraction in one process, lower solvent consumption, cost-effectiveness, and short analysis time. The use of multiple templates to prepare a MIP reduces the effort required to prepare different MIPs for different analytes separately. Although there are many studies about developing MT-MIP, there are no review articles that discuss the success rate of MT-MIP. Therefore, in this review, we summarise MT-MIP synthesis, including the polymerisation method being used, the important factors that affect the quality of MT-MIP, and MT-MIP applications. MT-MIP has great potential in chemical isolation and analysis. MT-MIP produces a product that has good sensitivity, selectivity, and reusability. Furthermore, many templates, functional monomers, and crosslinkers can be formulated as MT-MIP and have a high success rate. This is evidenced by the good values of the maximum absorption capacity (Qmax), imprinting factor (IF), and reusability. We expect that the evidence presented in this review can encourage additional research on the development and application of MT-MIP.

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Section: Multi-template Strategymentioning

confidence: 99%

Section: Multi-template Strategymentioning

confidence: 99%

A Review: Using Multiple Templates for Molecular Imprinted Polymer: Is It Good?

et al. 2022

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“…Oleh sebab itu, perlu dilakukan deteksi CAP secara akurat pada produk hewan untuk meminimalisir masalah diatas, salah satunya menggunakan instrumen High Performance Liquid Chromatography (HPLC). HPLC dipilih karena memiliki tingkat keakurasian dan sensitivitas yang tinggi, sehingga dapat digunakan untuk mendeteksi CAP secara akurat [6,7]. Namun, karena keberadaan CAP pada produk hewan pada umumnya dijumpai dalam konsentrasi yang rendah, maka sebelum melakukan instrumentasi perlu dilakukan pretreatment, salah satunya dengan cara pemekatan atau pre-concentration menggunakan Molecularly Imprinted Polymer (MIP) [8].…”

Section: Gambar 8 Struktur Kloramfenikol [2]unclassified

Pengaruh Variasi Komposisi Ekstraktan Terhadap Kemampuan Adsorpsi Kloramfenikol Menggunakan Molecularly Imprinted Polymer (Mip)

Listiadi¹,

Sianita²

2021

UJC

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Penelitian ini bertujuan untuk mengoptimasi komposisi ekstraktan metanol:asam asetat dengan variasi 90:10(v/v), 85:15(v/v), dan 80:20(v/v) pada sintesis Molecularly Imprinted Polymer- Kloramfenikol (MIP-CAP). MIP-CAP diperoleh dari (Non Imprinted Polymer) NIP yang telah melalui proses ekstraksi template. Ekstraksi template menggunakan metode maserasi dan dianalisis menggunakan High Performance Liquid Chromatography (HPLC) untuk menentukan CAP terekstrak. Variasi komposisi ekstraktan terbaik ditentukan berdasarkan % ekstraksi dan kemampuan adsorpsi. Karakterisasi polimer MIP-CAP dilakukan dengan menggunakan Fourier Transform Infra Red (FTIR) untuk melihat keberadaan gugus –NO2. Pada penelitian dihasilkan komposisi ekstraktan metanol:asam asetat terbaik adalah 80:20 (v/v) (20% asam asetat) dengan perolehan % ekstraksi sebesar 89,5158% dan kemampuan adsorpsi sebesar 4,0725 mg/g dengan nilai Imprinting Factor (IF) sebesar 3,7369. Semakin tinggi penambahan asam asetat menyebabkan semakin tingginya % ekstraksi dan nilai kemampuan adsorpsi. Karaterisasi FTIR pada MIP-CAP menunjukkan tidak adanya serapan gugus -NO2. Kata kunci: CAP, MIP-CAP, Komposisi Ekstraktan

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“…Eventhough the Minister of Health Regulation banned the use of chloramphenicol, facts showed that in another research Saputra and Arfi in 'Analysis Chlorampenicol residue in shrimp' found 0,2 ppm chloramphenicol residue in shrimp [2], [3]. So the sophisticated method was needed to analyze the presense of Chloramphenicol in aquaculture, such as High Performance Liquid Chromatography (HPLC), ELISA, etc.…”

Section: Introductionmentioning

confidence: 99%

Calculation of enrichment factor in chloramphenicol analysis in shrimp with variation of concentration using molecularly imprinted polymer

Fahman¹,

Sianita²

2022

World J. Adv. Res. Rev.

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This research aims to determine the effect of chloramphenicol concentration in shrimp toward the value of enrichment factor (EF) in the adsorption-desorption process using Molecularly Imprinted Polymer (MIP) as adsorbent. The enrichment factor describes how much analyte concentration is transferred from the sample to the solvent. In this research, the highest enrichment factor (EF) value was obtuined for chloramphenicol concentration of 50 ppm which was 120,086%. The Scanning Electron Microscope (SEM) analysis showed that the sizes of Blank Polymer (PB), Non-Imprinted Polymer (NIP), and Molecularly Imprinted Polymer (MIP) were 12, 18, and 23 nm, respectively. The detection limit value (LOD) was 0.0981 μg/mL, and the quantitation limit value (LOQ) was 0.3273 μg/mL. At this limit of detection (LOD) no chloramphenicol was detected in the analyzed shrimp.

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A nanosorbent consisting of a magnetic molecularly imprinted polymer and graphene oxide for multi-residue analysis of cephalosporins

Cited by 35 publications

References 29 publications

A Review: Using Multiple Templates for Molecular Imprinted Polymer: Is It Good?

A Review: Using Multiple Templates for Molecular Imprinted Polymer: Is It Good?

Pengaruh Variasi Komposisi Ekstraktan Terhadap Kemampuan Adsorpsi Kloramfenikol Menggunakan Molecularly Imprinted Polymer (Mip)

Calculation of enrichment factor in chloramphenicol analysis in shrimp with variation of concentration using molecularly imprinted polymer

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