A myelographic manifestation of diffuse spinal leptomeningeal melanomatosis

Jacobsen, Helle J.; Lester, Jack

doi:10.1007/bf00347656

Cited by 10 publications

(3 citation statements)

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“…The majority of spinal neoplasms represent sec ondary metastatic manifestation originating from neuro genic tumors and non-ncuraxial malignancy, as was the case in 5 of the 16 (31.2%) and 10 of the 16 (62.5%) patients, respectively. With 31 cases collected from the literature till 1974 [28] and few additional patients, including case 16. reported since [16][17][18][19][20], leptomeningeal melanoma is a rare entity. Acceptance as a representative of primary leptomeningeal neoplasm depends upon rigor ous elimination of any potential primary site [29], Symptomatic because of its invasive nature or mass effect, meningosis neoplástica is difficult to diagnose on clinical grounds [9, 14, 21.…”

Section: Discussionmentioning

confidence: 99%

“…1991 hematogenous route is assumed to predominate [7. 15] over perineural or perivascular extension [3,9], Primary leptomeningeal malignant melanoma that may mimic metastatic subarachnoid infiltration is rare [16][17][18][19][20].Diagnosis of leptomeningeal neoplastic disease is diffi cult to establish on clinical grounds and necessitates posi tive C SF cytology and morphologic evaluation of the spi nal canal. Several reports have stated the reliability of myelography [1.…”

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confidence: 99%

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Spinal Leptomeningeal Neoplastic Disease

et al. 1992

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Out of 16 patients, spinal leptomeningeal neoplastic disease was diagnosed by MRI in 4 patients, myelography in 14 patients and CT myelography in 12 cases. MR was superior to myelography in 2 patients, in another 2 patients MRI was equally diagnostic. The cerebrospinal fluid of every patient contained malignant cells. Histological evidence for primary central nervous system tumors was found in 5 cases. In 10 cases, non-neuraxial malignancy consisted of small cell carcinoma of the lung (7 cases), and leukemia and lymphoma (3 patients). In 1 patient, primary leptomeningeal malignant melanoma was confirmed at autopsy. Preferential thoracolumbar neoplastic morphologic manifestation correlated with the presence of conus and cauda equina syndrome in 9 patients, low back pain, paresthesia and spinal root signs in 7 patients. False-negative interpretation of myelography in 2 patients with positive MR findings, and the impressive sensitivity of gadolinium Dota to improve visualization of subarachnoid spread, favor MRI as an alternative imaging technique in the assessment of patients with suspected intradural extramedullary malignancy.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Spinal Leptomeningeal Neoplastic Disease

et al. 1992

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“…In particular, the water soluble contrast medium Metrizamide has been reported to permit visualization of small metastatic deposits in the subarachanoid space (7,8). In particular, the water soluble contrast medium Metrizamide has been reported to permit visualization of small metastatic deposits in the subarachanoid space (7,8).…”

Section: Introductionmentioning

confidence: 99%

Metrizamide myelography in patients with small cell carcinoma of the lung suspected of meningeal carcinomatosis

Pedersen¹,

Paulson²,

Gyldensted³

1985

J Neuro-Oncol

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Twenty patients suspected of meningeal carcinomatosis (MC) secondary to small cell carcinoma of the lung were evaluated by myelography and by cytologic examination of cerebrospinal fluid (CSF). In 4 patients both investigations demonstrated MC. Four had positive cytology but a negative myelogram. Five patients had a positive myelogram but negative cytology. Thus 13 of the 20 patients had MC diagnosed by one or both of these investigations. Two additional patients suspected of MC were studied; both had positive myelography, but cytologic examination of CSF was not performed in either case. Six patients underwent autopsy with microscopic examination of the spinal cord; in all cases post-mortem findings supported myelographic findings. In conclusion, myelography is useful in the evaluation of patients suspected of MC secondary to small carcinoma of the lung and complements the diagnostic role of CSF examination.

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