A multisite phase III study of the safety and efficacy of a new manganese chloride-based gastrointestinal contrast agent for MRI of the abdomen and pelvis

Small, William; DeSimone-Macchi, Debra; Parker, John R.; Sukerkar, Arun N.; Hahn, Peter F.; Rubin, Daniel L.; Zelch, James V.; Kuhlman, Janet E.; Outwater, Eric K.; Weinreb, Jeffrey C.; Brown, Jeffrey J.; Lange, Eduard E. de; Woodward, Paula J.; Arildsen, Ronald C.; Foster, Gregory S.; Runge, Val M.; Aisen, Alex M.; Muroff, Lawrence R.; Thoeni, Ruedi F.; Parisky, Yuri R.; Tanenbaum, Lawrence N.; Tötterman, S.; Herfkens, Robert J.; Knudsen, John M.; Laster, Robert E.; Duerinckx, André J.; Stillman, Arthur E.; Spritzer, Charles E.; Saini, Sanjay; Rofsky, Neil M.; Bernardino, Michael E.

doi:10.1002/(sici)1522-2586(199907)10:1<15::aid-jmri3>3.0.co;2-x

Cited by 53 publications

(22 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although MnCl 2 is used as an MRI contrast agent for the gastrointestinal tract in human, 25 systemic administration of MnCl 2 at the concentration used in this study is restrained in human applications because of its toxicity. 26 Therefore, we conducted MEMRI of the pleural tumors using MnDPDP, an Mn-releasing contrast agent used for human liver imaging.…”

Section: Discussionmentioning

confidence: 99%

Molecular imaging of mesothelioma by detection of manganese‐superoxide dismutase activity using manganese‐enhanced magnetic resonance imaging

Hasegawa

Koshikawa-Yano²,

Saito

et al. 2011

Intl Journal of Cancer

View full text Add to dashboard Cite

Malignant mesothelioma (MM) is a fatal malignancy with a rapidly increasing incidence in industrialized countries because of the widespread use of asbestos in the past centuries. Early diagnosis of MM is critical for a better prognosis, but this is often difficult because of the lack of disease-specific diagnostic imaging. Here, we report that manganese-enhanced magnetic resonance imaging (MEMRI) represents a promising approach for a more selective mesothelioma imaging by monitoring a high-level expression of manganese-superoxide dismutase (Mn-SOD), which is observed in many MM. We found that most human MM cells overexpressed Mn-SOD protein compared with human mesothelial cells and that NCI-H226 human MM cells highly expressed Mn-SOD and augmented Mn accumulation when loaded with manganese chloride (MnCl 2 ). The cells showed marked T 1 -signal enhancement on in vitro MRI after incubation with MnCl 2 because of the T 1 shortening effect of Mn 21 . H226subcutaneous tumor was preferentially enhanced compared with a lung adenocarcinoma cell tumor and another human MM cell tumor in MnCl 2 -enhanced T 1 -weighted MR image (T 1 WI), correlating with their respective Mn-SOD expression levels. Moreover, in a more clinically relevant setting, H226 xenografted pleural tumor was markedly enhanced and readily detected by MEMRI using manganese dipyridoxyl diphosphate (MnDPDP), a clinically used contrast agent, as well as MnCl 2 . Therefore, we propose that MEMRI can be a potentially powerful method for noninvasive detection of MM, with high spatial resolution and marked signal enhancement, by targeting Mn-SOD.Malignant mesothelioma (MM) is an asbestos-related malignant tumor originating from mesothelial cells lining pleural and peritoneal cavities. There is a long latency period (more than 30 years) between the asbestos exposure and the onset of the disease, and the number of patients is now rapidly increasing in industrialized countries because of the widespread use and installation of asbestos fibers in the past centuries. Epidemiological studies indicate that the incidence is rapidly increasing worldwide.

show abstract

Section: Discussionmentioning

confidence: 99%

Molecular imaging of mesothelioma by detection of manganese‐superoxide dismutase activity using manganese‐enhanced magnetic resonance imaging

Hasegawa

Koshikawa-Yano²,

Saito

et al. 2011

Intl Journal of Cancer

View full text Add to dashboard Cite

show abstract

“…For T 1 -weighted images, most authors use gradient echo sequences in two-and three-dimensional acquisition modes with or without fat saturation prepulses (Figure 1), whereas for T 2 -weighted images, TSE and HASTE sequences are commonly employed. 2,19,20 More recently, the true FISP sequence has been successfully applied in bowel imaging, 12 providing high-resolution images of the bowel wall ( Figure 2) and additional information from the mesentery. Fat-suppressed TSE or STIR sequences have been also applied to assess activity in Crohn's disease.…”

Section: Pulse Sequencesmentioning

confidence: 99%

Magnetic resonance imaging evaluation of small intestinal Crohn's disease

Gourtsoyiannis

Papanikolaou

Karantanas

2006

Best Practice & Research Clinical Gastroenterology

View full text Add to dashboard Cite

“…While recent advances have been made in the search for water soluble manganese-based small molecule contrast agents,6-12 only two Mn 2+ -containing contrast agents have been approved for clinical use. [Mn(dipyridoxyldiphosphate)] 4− is the paramagnetic component of Teslascan®, a liver imaging agent13,14 while LumenHance®, which contains MnCl 2 , is employed in GI imaging 15…”

Section: Introductionmentioning

confidence: 99%

Correlation of Relaxivity with Coordination Number in Six-, Seven-, and Eight-Coordinate Mn(II) Complexes of Pendant-Arm Cyclen Derivatives

2008

View full text Add to dashboard Cite

The syntheses and characterization of several complexes of Mn(II) with cyclen derivatives having variable numbers of pendant N-acetic acid or N-acetamide arms are reported. X-ray crystallographic results are presented for Mn(DOTAM)Cl2·2H2O (monoclinic C2/c, a=18.5798(15), b=13.6006(11), c=10.5800(8) Å, β=110.490(1)°, Z=4), [Mn(DO3AM)][MnCl4]·EtOH (monoclinic P21/n, a=8.366(8), b=19.483(2), c=16.3627(16) Å, β=99.254(2)°, Z=4), and Mn(H2DOTA) (monoclinic C2/c, a=16.374(3), b=6.6559(13), c=16.750(3) Å, β=98.381(3)°, Z=4), which exhibit 8-, 7-, and 6-coordinate Mn(II), respectively. 1H relaxivity data in water at 20 MHz and 37°C is presented and interpreted in terms of a mechanism involving transient binding of water in an associative intermediate. Relaxivity studies in mixed water/methanol solvents are consistent with this interpretation.

show abstract

A multisite phase III study of the safety and efficacy of a new manganese chloride-based gastrointestinal contrast agent for MRI of the abdomen and pelvis

Cited by 53 publications

References 27 publications

Molecular imaging of mesothelioma by detection of manganese‐superoxide dismutase activity using manganese‐enhanced magnetic resonance imaging

Molecular imaging of mesothelioma by detection of manganese‐superoxide dismutase activity using manganese‐enhanced magnetic resonance imaging

Magnetic resonance imaging evaluation of small intestinal Crohn's disease

Correlation of Relaxivity with Coordination Number in Six-, Seven-, and Eight-Coordinate Mn(II) Complexes of Pendant-Arm Cyclen Derivatives

Contact Info

Product

Resources

About