A multiple cell-culture toxicity test system based on neuroblastoma C1300 cells and differentiated primary cultures of brain, muscle, heart and liver cells

MEIC—A new international multicenter project to evaluate the relevance to human toxicity of in vitro cytotoxicity tests

“…There are several assumptions underlying this program, as well as a set of hypotheses which have emerged as the result of previous, preliminary evaluation studies of the predictivity of general toxicity by in vitro tests (Ekwall, 1980;Ekwall, 1983a;Walum and Peterson, 1984;Walum et al, 1986;Bernson et al, 1986;Knox et al, 1986;Ekwall and Ekwall, 1988). The two main assumptions are indeed the incentives to the project, while a sries of hypotheses rather are hints by the previous research, to be confirmed or counterproven by the present project.…”

MEIC—A new international multicenter project to evaluate the relevance to human toxicity of in vitro cytotoxicity tests

“…There are several assumptions underlying this program, as well as a set of hypotheses which have emerged as the result of previous, preliminary evaluation studies of the predictivity of general toxicity by in vitro tests (Ekwall, 1980;Ekwall, 1983a;Walum and Peterson, 1984;Walum et al, 1986;Bernson et al, 1986;Knox et al, 1986;Ekwall and Ekwall, 1988). The two main assumptions are indeed the incentives to the project, while a sries of hypotheses rather are hints by the previous research, to be confirmed or counterproven by the present project.…”

MEIC—A new international multicenter project to evaluate the relevance to human toxicity of in vitro cytotoxicity tests

“…There are several assumptions underlying this program, as well as a set of hypotheses which have emerged as the result of previous, preliminary evaluation studies of the predictivity of general toxicity by in vitro tests (Ekwall, 1980;Ekwall, 1983a;Walum and Peterson, 1984;Walum et al, 1986;Bernson et al, 1986;Knox et al, 1986;Ekwall and Ekwall, 1988). The two main assumptions are indeed the incentives to the project, while a sries of hypotheses rather are hints by the previous research, to be confirmed or counterproven by the present project.…”

MEIC—A new international multicenter project to evaluate the relevance to human toxicity of in vitro cytotoxicity tests

“…There are several assumptions underlying this program, as well as a set of hypotheses which have emerged as the result of previous, preliminary evaluation studies of the predictivity of general toxicity by in vitro tests (Ekwall, 1980;Ekwall, 1983a;Walum and Peterson, 1984;Walum et al, 1986;Bernson et al, 1986;Knox et al, 1986;Ekwall and Ekwall, 1988). The two main assumptions are indeed the incentives to the project, while a sries of hypotheses rather are hints by the previous research, to be confirmed or counterproven by the present project.…”