1987
DOI: 10.1177/026119298701400305
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Abstract: A programme for a multicentre evaluation study of in vitro cytoxicity (MEIC) is proposed. The programme will try to evaluate the correlation between both lethal and sublethal toxic effects in man and in vitro cytotoxicity. Animal toxicity data will be included, to provide an opportunity for evaluating the species gap between man and laboratory animals. A list of chemicals to be used in this study is presented.

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Cited by 4 publications
(2 citation statements)
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“…Because of this concern, many efforts have been made to find acceptable substitutes for the rodent LD 50 test, such as in vitro cytotoxicity assays. [5][6][7][8][9][10][11] Bernson et al 12 proposed a 'Multicentre Evaluation Study of In vitro Cytotoxicity' (MEIC), based on a set of 50 very diverse organic and inorganic chemicals. The MEIC chemicals, as they came to be known, have been widely studied.…”
Section: Introductionmentioning
confidence: 99%
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“…Because of this concern, many efforts have been made to find acceptable substitutes for the rodent LD 50 test, such as in vitro cytotoxicity assays. [5][6][7][8][9][10][11] Bernson et al 12 proposed a 'Multicentre Evaluation Study of In vitro Cytotoxicity' (MEIC), based on a set of 50 very diverse organic and inorganic chemicals. The MEIC chemicals, as they came to be known, have been widely studied.…”
Section: Introductionmentioning
confidence: 99%
“…Bernson et al 12 proposed a ‘Multicentre Evaluation Study of In vitro Cytotoxicity’ (MEIC), based on a set of 50 very diverse organic and inorganic chemicals. The MEIC chemicals, as they came to be known, have been widely studied.…”
Section: Introductionmentioning
confidence: 99%