A multicenter study of the clinical characteristics of usual‐type vulvar intraepithelial neoplasia in China

Abstract

Age-specific differences were noted in location of neoplastic lesions in the lower genital tract and time to diagnosis of uVIN. However, the clinical features of uVIN lesions were heterogeneous and non-age specific.

Prevalence and type distribution of human papillomavirus in squamous cell carcinoma and intraepithelial neoplasia of the vulva

“…In all but one study, HPV ascertainment was based on biopsy specimens, which give the most reliable results and decrease the risk of contamination from other lesions . In one study, HPV detection in VIN lesions was performed on exfoliated cells . There are also some limitations that need to be considered.…”

“…41 In one study, HPV detection in VIN lesions was performed on exfoliated cells. 42 There are also some limitations that need to be considered. Even though we only included studies using a PCR-based test or a hybrid capture test, variation in the sensitivity of testing methods between studies remains.…”

Vulvar intraepithelial neoplasia

“…Usually, the same type of HPV is involved in all the lesions [31]. Younger patients have a higher risk of multifocal lesions (59% in women aged 20e34 and 10% in patients >50 years of age) [33], but older patients have more often intraepithelial lesions at uncommon sites (vagina, anus, and periurethral region) [34]. A model is constructed in a recent paper where a positive history for anal penetrative sex, immunosuppression, and VIN has a predictive probability of anal intraepithelial neoplasia of 71.8% [35].…”