A Multicenter Placebo-Controlled, Double-Blind Trial of Urapidil, an &amp;alpha;-Blocker, on Neurogenic Bladder Dysfunction

Yamanishi, Tomonori; Yasuda, Kosaku; Homma, Yukio; Kawabe, Kazuki; Morita, Takashi

doi:10.1159/000019818

Cited by 30 publications

(37 citation statements)

References 17 publications

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“…dose of urapidil was administered for 2 weeks followed by 30 mg b.i.d. for 2 weeks to avoid first phenomenon 21 . The effectiveness of each therapy was assessed 4 weeks after initialization of the therapy.…”

Section: Methodsmentioning

confidence: 99%

Combination of a cholinergic drug and an α‐blocker is more effective than monotherapy for the treatment of voiding difficulty in patients with underactive detrusor

et al. 2004

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Aim: The aim of the present study was to compare the effectiveness of a cholinergic drug, an ablocker and combinations of the two for the treatment of underactive detrusor. Methods: One hundred and nineteen patients with underactive bladder were assigned to three groups: the cholinergic group, consisting of 40 patients taking bethanechol chloride (60 mg/day) or distigmine bromide (15 mg/day); the a-blocker group, consisting of 38 patients taking urapidil (60 mg/ day); and the combination group, consisting of 41 patients taking both a cholinergic drug and an ablocker. The effectiveness of each therapy was assessed 4 weeks after initialization of the therapy. Results: Total urinary symptom scores (International Prostate Symptom Score, IPSS) remained unchanged after the cholinergic therapy, but were significantly lower after the a-blocker treatment (P = 0.0001) and the combination therapy (P = 0.0001). With regard to the total IPSS, there were significant differences between the cholinergic and the a-blocker groups (P = 0.0008), and also between the cholinergic and combination groups (P = 0.0033), in favor of the latter. The average and maximum flow rates did not increase significantly after monotherapy with either the cholinergic drug or the a-blocker, but they significantly increased after combination therapy compared to baseline values (P = 0.0033 and P = 0.0004, respectively). Postvoid residual volume did not decrease significantly after the cholinergic drug therapy, but decreased significantly after the a-blocker (P = 0.0043) and the combination therapies (P = 0.0008). The percentage of residual urine decreased significantly after therapy in all groups (P = 0.0005, P = 0.0176 and P = 0.0001, respectively). Conclusion: Combination therapy with a cholinergic drug and an a-blocker appears to be more useful than monotherapy for the treatment of underactive detrusor.

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Section: Methodsmentioning

confidence: 99%

Combination of a cholinergic drug and an α‐blocker is more effective than monotherapy for the treatment of voiding difficulty in patients with underactive detrusor

et al. 2004

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“…However, it is worth noting that positive testing in patients with past BCG might not be false positive but signal for undetected recurrence as suggested by Pode et al [12]. Additionally, a positive BTA stat Test may indicate early detection of subclinical oncoming recurrence [10], a suggestion that has recently been supported by Leyh et al [16]and Pode et al [12]. In the series of Sarosdy et al [10], 31% of 29 patients with a positive test result and negative cystoscopy developed a recurrence between 3 and 12 months later.…”

Section: Discussionmentioning

confidence: 98%

“…It has been reported to have equal or often better sensitivity than cytology not only in the diagnosis of primary but also of recurrent bladder tumor [8, 12, 16]. The specificity of the BTA stat Test has also been reported to be very high [10, 11].…”

Section: Discussionmentioning

confidence: 99%

Effect of Intravesical Instillations on the Human Complement Factor H Related Protein (BTA <i>stat</i>) Test

et al. 2001

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“…Previously, we reported a considerable variation in £ow rate, and the greatest £ow rate was obtained in a prone or bending-forward position in normal volunteers [Yamanishi et al, 1999a]. Additional use of alpha-blockers may be e¡ective in obtaining a balanced bladder even in patients with acontractile detrusor [Fanciullacci, 1994;Yamanishi et al, 1999b;Orendacova et al, 2001]. …”

Section: Discussionmentioning

confidence: 99%

Urodynamic evaluation of surgical outcome in patients with urinary retention due to central lumbar disc prolapse

Yamanishi

Yasuda

Yuki

et al. 2003

Neurourology and Urodynamics

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A Multicenter Placebo-Controlled, Double-Blind Trial of Urapidil, an α-Blocker, on Neurogenic Bladder Dysfunction

Cited by 30 publications

References 17 publications

Combination of a cholinergic drug and an α‐blocker is more effective than monotherapy for the treatment of voiding difficulty in patients with underactive detrusor

Combination of a cholinergic drug and an α‐blocker is more effective than monotherapy for the treatment of voiding difficulty in patients with underactive detrusor

Effect of Intravesical Instillations on the Human Complement Factor H Related Protein (BTA <i>stat</i>) Test

Urodynamic evaluation of surgical outcome in patients with urinary retention due to central lumbar disc prolapse

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