A multi-centre prospective development study evaluating focal therapy using high intensity focused ultrasound for localised prostate cancer: The INDEX study

Dickinson, Louise; Ahmed, Hashim U.; Kirkham, Alex; Allen, Clare; Freeman, Alex; Barber, Julie; Hindley, Richard G.; Leslie, Tom; Ogden, Chris; Persad, Raj; Winkler, Mathias; Emberton, Mark

doi:10.1016/j.cct.2013.06.005

Cited by 69 publications

(48 citation statements)

References 50 publications

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“…The modalities described were cryoablation [5][6][7][8][9][10][11][12], HIFU [6,[13][14][15][16][17], IRE [6,[13][14][15][16][17][18][19][20][21], laser ablation therapy [22][23][24], VTP [6,[25][26][27][28] and brachytherapy [6,29].…”

Section: Systematic Searchmentioning

confidence: 99%

“…Commonly reported measures of treatment efficacy are prostate-specific antigen (PSA) dynamics after treatment [5-17, 20-22, 25, 26, 28, 29], the presence of suspicious areas on follow-up MRI [13,14,16,18,[20][21][22]25] and follow-up biopsy results. The planned follow-up biopsy scheme varies: in some protocols both the treated zone and the untreated zone are biopsied in every patient [5, 7-11, 15, 17, 19, 25-27, 29].…”

Section: Treatment Efficacymentioning

confidence: 99%

“…Baseline and post-treatment PSA dynamics are reported by most papers [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][24][25][26][27][28][29]. The more specific "biochemical recurrence" is reported by few papers and different definitions were used: The original ASTRO definition of three consecutive rises above the nadir was used by five authors [5,8,10,11,17].…”

Section: Biochemical Statusmentioning

confidence: 99%

“…Different definitions for potency were in use besides the standardized questionnaires: the combination of achieving erections sufficient for vaginal penetration and being satisfied with sexual functioning regardless of the use of oral medication [10,11], erections sufficient for vaginal penetration allowing phosphodiesterase-5 inhibitors [8,14], erections sufficient for vaginal penetration without stating whether medication is allowed [9,13,20,21], and the ability to maintain an erection when stimulated with or without oral medication [5]. However, many papers that reported potency as an outcome did not state how it is defined [6,12,15,16,18,19,22,24,25,27,28]. Durand et al [7] reported the number of patients who are sexually active before and after treatment without providing a definition.…”

Section: Sexual Functionmentioning

confidence: 99%

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834 Standardization in definitions in focal therapy for prostate cancer: Report from a Delphi consensus project

Postema¹,

Reijke²,

Ukimura³

et al. 2016

European Urology Supplements

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questionnaires. During a face-to-face meeting on June 21, 2015, attended by 38 experts, all data from the online rounds were reviewed and recommendations for definitions were formulated. Results Consensus was attained on 23 of 27 topics; Targeted FT was defined as a lesion-based treatment strategy, treating all identified significant cancer foci; FT was generically defined as an anatomy-based (zonal) treatment strategy. Treatment failure due to the ablative energy inadequately destroying treated tissue is defined as ablation Abstract

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Section: Systematic Searchmentioning

confidence: 99%

Section: Treatment Efficacymentioning

confidence: 99%

Section: Biochemical Statusmentioning

confidence: 99%

Section: Sexual Functionmentioning

confidence: 99%

See 2 more Smart Citations

834 Standardization in definitions in focal therapy for prostate cancer: Report from a Delphi consensus project

Postema¹,

Reijke²,

Ukimura³

et al. 2016

European Urology Supplements

View full text Add to dashboard Cite

show abstract

“…A large, multicentre trial is underway to evaluate disease control and long-term follow-up (Dickinson et al 2013 ). Complications of modern series with HIFU may be summarised as stress incontinence, 5-10 %; fi stula, 0-0.7 %; stricture, 9-12 %; UTI, 5-13 % and impotence, 55-70 % (Aus 2006 ) (Fig.…”

Section: High-intensity Focused Ultrasound (Hifu)mentioning

confidence: 99%

Female Pelvis: Genital Organs

Forstner

Cunha²

2015

Imaging of Complications and Toxicity Following Tumor Therapy

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Medical Radiology-Diagnostic Imaging is a unique series that aims to document the most innovative technologies in all fi elds within diagnostic imaging and interventional radiology, thereby informing the physician in practice of the latest advances in diagnostic imaging and percutaneous imageguided minimally invasive procedures. Th e contents are intended to cover all organs, and all modern imaging techniques and image-guided treatment modalities, with special emphasis on applications in clinical practice. Each volume is a comprehensive reference book on a topical theme, and the editors are always experts of high international standing. Contributions are included from both clinicians and researchers, ensuring wide appeal. Medical Radiology -Radiation Oncology is a unique series that aims to document the most innovative technologies in all fi elds within radiology, thereby informing the physician in practice of the latest advances in diagnostic and treatment techniques. Th e contents range from contemporary statements relating to management for various disease sites to explanations of the newest techniques for tumor identifi cation and of mechanisms for the enhancement of radiation eff ects, with the emphasis on maximizing cure and minimizing complications. Each volume is a comprehensive reference book on a topical theme, and the editors are always experts of high international standing. Contributions are included from both clinicians and researchers, ensuring wide appeal. This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifi cally the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfi lms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specifi c statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. AbstractA precise knowledge of antineoplastic drugs is an indispensable basis for the care of patients with cancer. The mechanisms of action and resistance, cross-resistance patterns, pharmacodynamics and pharmacokinetics, pharmacological interaction, and last but not least potential adverse effects should be part of this knowledge. As contemporary cancer care requires interdisciplinary and multiprofessional structures, the radiologist is an important a...

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Primary cryotherapy for localised or locally advanced prostate cancer

Jung

Goldfarb

Reddy

et al. 2018

Cochrane Database of Systematic Reviews

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BackgroundTraditionally, radical prostatectomy and radiotherapy with or without androgen deprivation therapy have been the main treatment options to attempt to cure men with localised or locally advanced prostate cancer. Cryotherapy is an alternative option for treatment of prostate cancer that involves freezing of the whole prostate (whole gland therapy) or only the cancer (focal therapy), but it is unclear how effective this is in comparison to other treatments. ObjectivesTo assess the effects of cryotherapy (whole gland or focal) compared with other interventions for primary treatment of clinically localised (cT1-T2) or locally-advanced (cT3) non-metastatic prostate cancer. Search methodsWe updated a previously published Cochrane Review by performing a comprehensive search of multiple databases (CENTRAL, MEDLINE, EMBASE), clinical trial registries (ClinicalTrials.gov, World Health Organization International Clinical Trials Registry Platform) and a grey literature repository (Grey Literature Report) up to 6 March 2018. We also searched the reference lists of other relevant publications and conference proceedings. We applied no language restrictions. Selection criteriaWe included randomised or quasi-randomised trials comparing cryotherapy to other interventions for the primary treatment of prostate cancer. Data collection and analysisTwo independent reviewers screened the literature, extracted data, and assessed risk of bias. We performed statistical analyses using a random-effects model and interpreted them according to the Cochrane Handbook for Systematic Reviews of Interventions. We rated the quality of evidence (QoE) according to the GRADE approach.

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A multi-centre prospective development study evaluating focal therapy using high intensity focused ultrasound for localised prostate cancer: The INDEX study

Cited by 69 publications

References 50 publications

834 Standardization in definitions in focal therapy for prostate cancer: Report from a Delphi consensus project

834 Standardization in definitions in focal therapy for prostate cancer: Report from a Delphi consensus project

Female Pelvis: Genital Organs

Primary cryotherapy for localised or locally advanced prostate cancer

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