A morphologic, biochemical, and biomechanical assessment of short-term effects of osteochondral autograft plug transfer in an animal model

Lane, Joseph R.; Tontz, William; Ball, Scott T.; Massie, Jennifer B.; Chen, Albert C.; Bae, Won C.; Amiel, Michael E.; Sah, Robert L.; Amiel, David

doi:10.1016/s0749-8063(01)90010-6

Cited by 78 publications

(58 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Transplantation of fresh autograft plugs demonstrated an increase in the sulfate-uptake of grafts over control [29]. We observed similarly increased rates of 35sulfate incorporation with allografts being intermediate between autografts and normal tissue.…”

Section: D Gole Et Al I Journal Of Orthopaedic Research 22 (2004supporting

confidence: 63%

Chondrocyte viability in press‐fit cryopreserved osteochondral allografts

Gole

Poulsen

Marzo

et al. 2004

Journal Orthopaedic Research

View full text Add to dashboard Cite

The viability of chondrocytes in press-fit glycerol-preserved osteochondral allografts was compared to that in fresh autografts, after transplantation into load-bearing and non-load-bearing sites in mature sheep stifle joints. We used macroscopic grading, tonometer pen indentation testing, histology, sulfate uptake and viability as determined by confocal-microscopy to assess cartilage condition. Despite there being no statistical differences between macroscopic appearance and tonometer testing of all grafts, confocal microscopy and histology demonstrated a positive effect of load-bearing placement on cryopreserved osteochondral allografts. Allografts transplanted into load-bearing sites demonstrated superior confocal microscopy-measured chondrocyte viability (77% ? 17%1sD) than those transplanted into non-load-bearing sites (25% f 2%). Load-bearing effect was not seen in autografts (78% k ISXI), and was comparable in adjacent cartilage (830/0 5 9%). Similarly, load-bearing allografts demonstrated histological scoring closer to that of autografts and adjacent cartilage, all of which fared significantly better than non-load-bearing allografts. Load-bearing allografts had a greater amount of fibrocartilage than autografts or adjacent cartilage but less fibrocartilage than nonload-bearing allografts. Both autografts and allografts had non-significant increases in metabolism compared to adjacent cartilage as measured by sulfate-uptake. Load-bearing placement improved chondrocyte viability of glycerol cryopreserved osteochondral allograft following a press-fit implantation. Published by Elsevier Ltd. on behalf of orthopaedic Research Society.

show abstract

Section: D Gole Et Al I Journal Of Orthopaedic Research 22 (2004supporting

confidence: 63%

Chondrocyte viability in press‐fit cryopreserved osteochondral allografts

Gole

Poulsen

Marzo

et al. 2004

Journal Orthopaedic Research

View full text Add to dashboard Cite

show abstract

“…23 In multiple studies including rabbit, ovine, and porcine models, chondrocytes and osteocytes of the osteochondral graft have been shown to survive transplantation. [24][25][26][27][28][29][30] Osteochondral grafting has also been used in the capitellum, talus, and femoral head, with graft viability proven with second-look arthroscopy, MRI, and biopsy. [31][32][33][34][35][36][37] The MRI of our patient at 21 months postoperative showed bone incorporation of the graft to the capitate and the presence of graft cartilage (►Fig.…”

Section: Discussionmentioning

confidence: 99%

Technique: Osteochondral Grafting of Capitate Chondrosis in PRC

Tang

Imbriglia

2013

Jnl Wrist Surg

View full text Add to dashboard Cite

Proximal row carpectomy (PRC) has been shown in multiple studies to be an effective motion-preserving procedure for wrist arthritis. The operation consists of resection of the scaphoid, lunate, and triquetrum. 1 The proximal capitate and lunate fossa of the radius form the new wrist articulation, which makes the ideal patient free of degenerative changes at those articular surfaces. 2-8 Various authors, as well as the senior author, have maintained that when there is mild degeneration of these articular surfaces, PRC can still provide good to excellent results. [2][3][4][5][6]9 However, as wrist arthritis progresses, as in stage III scapholunate advanced collapse (SLAC) wrist or stage II/III scaphoid nonunion advanced collapse (SNAC) wrist, the proximal capitate becomes arthritic. With advanced degeneration, alternative surgical procedures include scaphoid excision, four-bone fusion, and wrist fusion. However, there Keywords ► osteochondral graft ► proximal row carpectomy AbstractBackground Proximal row carpectomy (PRC) is a useful treatment option for wrist arthritis, but the operation is contraindicated when there is arthritis of the capitate head. We describe a technique that involves resurfacing of a capitate that has focal chondrosis, using an osteochondral graft harvested from the resected carpal bones. Materials and Methods PRC patients who had a focal area of capitate chondrosis underwent osteochondral grafting of the capitate. Pre-and postoperative pain level, employment status, motion, grip strength, and Modified Mayo Wrist Scores (MMWS) were assessed. Postoperative Disability of the Arm, Shoulder, and Hand (DASH) scores were also calculated.

show abstract

“…Two studies of a goat osteochondral grafting model revealed that mechanical stiffness of grafted cartilage had increased after the surgery, comparing with contralateral control site [23,24]. The studies raise the question of whether osteochondral grafting causes these mechanical changes to the cartilage of osteochondral plugs [23,24].…”

Section: Discussionmentioning

confidence: 99%

“…The studies raise the question of whether osteochondral grafting causes these mechanical changes to the cartilage of osteochondral plugs [23,24]. Mechanical measurement during the osteochondral grafting surgery is necessary to clarify this question.…”

Section: Discussionmentioning

confidence: 99%

Ultrasound properties of articular cartilage immediately after osteochondral grafting surgery: in cases of traumatic cartilage lesions and osteonecrosis

Kuroki

Nakagawa

Mori

et al. 2008

Knee Surg Sports Traumatol Arthr

View full text Add to dashboard Cite

Although osteochondral grafting surgery is believed to replace damaged cartilage with healthy-looking normal cartilage, no study focuses on ultrasound quantification of those cartilage immediately after the surgery. It is unknown whether the ultrasound properties of damaged cartilage from trauma or osteonecrosis are same with each other. We have examined ultrasound properties of damaged cartilage, adjacent intact cartilage and plug cartilage during osteochondral grafting surgery for 15 knees of 15 patients, mean age of 43.4 (range, 14-61) years. Results showed that signal intensities of ultrasound (a measure of superficial cartilage integrity) of intact cartilage, damaged cartilage, and plug cartilage were 1.91 (arbitrary unit), 0.40, and 2.13, respectively, in 11 knees of 11 patients of traumatic cartilage lesions. Interval between signals of ultrasound (a parameter related to thickness) were 2.79 (ls), 1.90, and 2.85, respectively. The signal intensity and the interval between signals of plug cartilage were 533% (P \ 0.01) and 150% (P \ 0.01) of damaged cartilage, respectively.In four knees of four patients of osteonecrosis, the signal intensities of intact cartilage, damaged cartilage, and plug cartilage were 1.25, 0.30, and 1.39, respectively. The interval between signals were 2.36, 2.00, and 2.69, respectively. The signal intensity and the interval between signals of plug cartilage were 463% (P \ 0.01) and 135% (P \ 0.05) of damaged cartilage. We conclude that ultrasound properties of the damaged cartilage from trauma or osteonecrosis did not differ a lot especially in the late stages of osteonecrosis and that the osteochondral grafting surgery replaced the damaged cartilage with plug cartilage that had greater superficial cartilage integrity and greater thickness parameter immediately after the surgery. Longterm effect of the osteochondral grafting surgery should be verified in further study.

show abstract

A morphologic, biochemical, and biomechanical assessment of short-term effects of osteochondral autograft plug transfer in an animal model

Cited by 78 publications

References 19 publications

Chondrocyte viability in press‐fit cryopreserved osteochondral allografts

Chondrocyte viability in press‐fit cryopreserved osteochondral allografts

Technique: Osteochondral Grafting of Capitate Chondrosis in PRC

Ultrasound properties of articular cartilage immediately after osteochondral grafting surgery: in cases of traumatic cartilage lesions and osteonecrosis

Contact Info

Product

Resources

About