A Molecular Mechanism Regulating the Timing of Corticogeniculate Innervation

Brooks, J.; Su, Jianmin; Levy, Carl C.; Wang, Jessica S.; Seabrook, Tania A.; Guido, William; Fox, Michael A.

doi:10.1016/j.celrep.2013.09.041

Cited by 49 publications

(99 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Enucleation of the eye or genetic reduction of RGCs alters the timing of corticothalamic innervation (Brooks et al, 2013; Seabrook et al, 2013), while RGC axons fail to project to the dLGN in mice that develop without a cortex (Shanks et al, 2016). In the superior colliculus, the retinal input instructs alignment of the feedback projection, as genetic duplication of the retinocollicular map leads to bifurcation of the corticocollicular projection (Triplett et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…L6 corticothalamic cells modulate relay neuron firing in the adult via this direct, excitatory projection as well as through disynaptic inhibitory pathways (Figure 1A) (Crandall et al, 2015; Guillery and Sherman, 2002). Notably, development of the corticothalamic projection is delayed relative to retinal inputs, only completing innervation of the dLGN after eye opening (Brooks et al, 2013; Jacobs et al, 2007; Shatz and Rakic, 1981). Corticogeniculate inputs then strengthen functionally during the second phase of retinogeniculate refinement (Jurgens et al, 2012), just prior to onset of experience-dependent retinogeniculate rewiring.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cortical Feedback Regulates Feedforward Retinogeniculate Refinement

Thompson

Picard

Min

et al. 2016

Neuron

View full text Add to dashboard Cite

SUMMARY According to the prevailing view of neural development, sensory pathways develop sequentially in a feedforward manner, whereby each local microcircuit refines and stabilizes before directing the wiring of its downstream target. In the visual system, retinal circuits are thought to mature first and direct refinement in the thalamus, after which cortical circuits refine with experience-dependent plasticity. In contrast, we now show that feedback from cortex to thalamus critically regulates refinement of the retinogeniculate projection during a discrete window in development, beginning at postnatal day 20 in mice. Disrupting cortical activity during this window, pharmacologically or chemogenetically, increases the number of retinal ganglion cells innervating each thalamic relay neuron. These results suggest that primary sensory structures develop through the concurrent and interdependent remodeling of subcortical and cortical circuits in response to sensory experience, rather than through a simple feedforward process. Our findings also highlight an unexpected function for the corticothalamic projection.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cortical Feedback Regulates Feedforward Retinogeniculate Refinement

Thompson

Picard

Min

et al. 2016

Neuron

View full text Add to dashboard Cite

show abstract

“…Indeed, Chen and coworkers described a critical role for early-arriving ‘pioneer’ axons in targeting of subsequent-arriving axons to the zebrafish tectum (Pittman et al, 2008). Notably, the arrival of RGC axons in the dLGN regulates ingrowth timing of cortico-geniculate afferents by influencing repellent expression (Brooks et al, 2013; Seabrook et al, 2013). Thus, whether or not an axon chooses to bypass, transiently innervate, or stably connect to a given target may instruct that immediate target and downstream targets that together comprise parallel pathways.…”

Section: Discussionmentioning

confidence: 99%

Birthdate and Outgrowth Timing Predict Cellular Mechanisms of Axon Target Matching in the Developing Visual Pathway

et al. 2014

View full text Add to dashboard Cite

Summary How axons select their appropriate targets in the brain remains poorly understood. Here we explored the cellular mechanisms of axon-target matching in the developing visual system by comparing four transgenic mouse lines, each with a different population of genetically labeled retinal ganglion cells (RGCs) that connect to unique combinations of brain targets. We discovered that the time when an RGC axon arrives in the brain is correlated with its target selection strategy. Early-born, early-arriving RGC axons initially innervate multiple targets. Subsequently, most of those connections were removed. By contrast, later born, later-arriving RGC axons were highly accurate in their initial target choices. These data reveal the diversity of cellular mechanisms axons use to pick their targets and they highlight the key role of birthdate and outgrowth timing for influencing this precision. Timing-based mechanisms may underlie the assembly of the other sensory pathways and complex neural circuitry in the brain.

show abstract

“…Aggrecan expression prevents premature entry of corticothalamic axons into the lateral geniculate nucleus. Retinal inputs are able to control the timing of degradation of aggrecan, and in their absence, aggrecan is prematurely degraded, thus leading to accelerated innervation of corticothalamic inputs (Brooks et al, 2013). …”

Section: Insights From the Visual Systemmentioning

confidence: 99%

Impact of peripheral hearing loss on top-down auditory processing

Lesicko

Llano

2017

Hearing Research

View full text Add to dashboard Cite

The auditory system consists of an intricate set of connections interposed between hierarchically arranged nuclei. The ascending pathways carrying sound information from the cochlea to the auditory cortex are, predictably, altered in instances of hearing loss resulting from blockage or damage to peripheral auditory structures. However, hearing loss-induced changes in descending connections that emanate from higher auditory centers and project back toward the periphery are still poorly understood. These pathways, which are the hypothesized substrate of high-level contextual and plasticity cues, are intimately linked to the ascending stream, and are thereby also likely to be influenced by auditory deprivation. In the current report, we review both the human and animal literature regarding changes in top-down modulation after peripheral hearing loss. Both aged humans and cochlear implant users are able to harness the power of top-down cues to disambiguate corrupted sounds and, in the case of aged listeners, may rely more heavily on these cues than non-aged listeners. The animal literature also reveals a plethora of structural and functional changes occurring in multiple descending projection systems after peripheral deafferentation. These data suggest that peripheral deafferentation induces a rebalancing of bottom-up and top-down controls, and that it will be necessary to understand the mechanisms underlying this rebalancing to develop better rehabilitation strategies for individuals with peripheral hearing loss.

show abstract

A Molecular Mechanism Regulating the Timing of Corticogeniculate Innervation

Cited by 49 publications

References 32 publications

Cortical Feedback Regulates Feedforward Retinogeniculate Refinement

Cortical Feedback Regulates Feedforward Retinogeniculate Refinement

Birthdate and Outgrowth Timing Predict Cellular Mechanisms of Axon Target Matching in the Developing Visual Pathway

Impact of peripheral hearing loss on top-down auditory processing

Contact Info

Product

Resources

About