A Molécula de Lesão Renal-1 está Associada à Nefropatia Induzida por Contraste em Pacientes Idosos com IAMSSST

Huyut, Mustafa Ahmet

doi:10.36660/abc.20200172

Cited by 1 publication

(1 citation statement)

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“…The indiscriminate use of Iodinated Contrast (IC) means in coronary interventions contributes to the third cause of in-hospital acute kidney injury (AKI); contrast-induced nephropathy (CIN), which has an incidence of 2% in the general population and 40% in the population with risk factors (1)(2)(3)(4). CIN is defined by the KDIGO criteria as an increase in serum creatinine of 0.5 mg/dl (44mmol/l) or an increase of 25% in relation to the baseline value, evaluated within 48 hours after contrast administration (5).…”

Section: Introductionmentioning

confidence: 99%

WITHDRAWN: L-Carnitine on contrast-induced nephropathy in diabetic rats

de Oliveira,

Couto,

Borges

et al. 2023

Preprint

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Background: The use of contrast media in coronary interventions favors diagnostic success. Contrast-induced nephropathy (CIN) is considered a frequent adverse event in the presence of the risk factor diabetes mellitus (DM). L-Carnitine is a lipid metabolism compound with a possible antioxidant effect. Objectives: to evaluate the effect of L-Carnitine on contrast-induced nephropathy in rats with diabetes mellitus. Method: twenty-eight male Wistar rats (250-300g) were randomized into four groups: Citrate (control); Diabetes (65mg/kg of intravenous streptozotocin); Diabetes+Iodinated contrast (meglumine sodium ioxathalamate 6ml/kg intraperitoneal-i.p, single dose); Diabetes+Iodinated contrast+L-Carnitine (50 mg/kg i.p. administered for 5 days). Physiological parameters were evaluated (weight, feed and water intake, glycemia and ratio of kidney weight to animal weight); renal function (inulin clearance, serum creatinine, urinary NGAL and urinary albumin); renal hemodynamics and oxidative profile (urine peroxides, thiols in renal tissue, thiobarbituric acid reactive substances in urine and urinary nitric oxide). Results: Contrast-induced nephropathy was confirmed by reduced renal blood flow, increased renal vascular resistance, reduced inulin clearance, increased serum creatinine, and urinary NGAL with increased oxidative peroxide and consumption of antioxidant enzymes. L-Carnitine favored the improvement of renal function and hemodynamics with recovery of redox imbalance. Conclusion: the use of L-Carnitine demonstrated a renoprotective and antioxidant effect.

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Section: Introductionmentioning

confidence: 99%