Young adults especially are vulnerable to depression during university years, with those taking up highly demanding courses like medicine showing high prevalence. Protective factors have been identified to moderate the negative effects of stress on a person. One such factor is resilience, which this study examined and its role in the relationship between stress and depression among medical students. The total population of medicine students enrolled during the data gathering was 510. Using Cochran's formula, a five percent (5%) margin of error and a confidence level of ninety five percent (95%), the sample population taken was 220. A hierarchical linear regression was performed first to examine the relationship between stress and depression, stress and resilience and depression and resilience. Stress and depression were found to be positively correlated while both stress and depression were found to be negatively correlated with resilience. Moderation analysis was then used to determine the extent of resilience's effect on the relationship between stress and depression. Results showed that resilience moderated the relationship between stress and depression among medical students.