A model system for measuring comparative toxicities of cardiotoxic drugs with cultured rat heart myocytes, endothelial cells and fibroblasts. I. Emetine, chloroquine and metronidazole

Absorption, distribution and excretion of3H-labeled cephaeline- and emetine-spiked ipecac syrup in rats

“…Emetine is a direct myotoxin which inhibits protein synthesis and disrupts mitochondrial oxidative phosphorylation 18). In animal experiments, emetine has been shown to cause cardiac toxicity as well 19,20). In the current study, high retention of 3H-EM was evident in most tissues, includingthe heart.…”

Absorption, distribution and excretion of3H-labeled cephaeline- and emetine-spiked ipecac syrup in rats

“…Emetine is a direct myotoxin which inhibits protein synthesis and disrupts mitochondrial oxidative phosphorylation 18). In animal experiments, emetine has been shown to cause cardiac toxicity as well 19,20). In the current study, high retention of 3H-EM was evident in most tissues, includingthe heart.…”

Corticotropin-Releasing Factor Produces a Protein Synthesis–Dependent Long-Lasting Potentiation in Dentate Gyrus Neurons

“…In both studies, ϳ5-10% of potentiation in pEPSP slope was still observed at the end of recording. This is probably because the dose chosen for the present study was moderate because higher concentration of both inhibitors was known to produce cell toxicity (Lindenboim et al 1995;Wenzel and Cosma 1984). In another study, Huang and Kandel (1995) have similarly reported that dopamine D1/D5 receptor activation also produces a protein synthesis-dependent longlasting potentiation of hippocampal neurons.…”

Kardiotoxizität des 5-Fluorouracil - Klinische Relevanz bei palliativer Radiochemotherapie von malignen Kopf-Hals-Tumoren -

“…Durch In-vitro-Untersuchungen konnte von Wenzel und Cosma [16] Die klinischen Beschwerden sprechen in unterschiedlichem Ausmaû auf eine antianginöse Therapie an. Bei einem Teil der Patienten verschwindet die klinische Symptomatik und EKG-Veränderung nach Gabe von Nitroglycerin, b-Rezeptorenblockern und besonders Kalzium-Antagonisten und die Zystostatikatherapie kann fortgesetzt werden.…”

Absorption, distribution and excretion of3H-labeled cephaeline- and emetine-spiked ipecac syrup in rats

“…Emetine is a direct myotoxin which inhibits protein synthesis and disrupts mitochondrial oxidative phosphorylation 18). In animal experiments, emetine has been shown to cause cardiac toxicity as well 19,20). In the current study, high retention of 3H-EM was evident in most tissues, includingthe heart.…”

Corticotropin-Releasing Factor Produces a Protein Synthesis–Dependent Long-Lasting Potentiation in Dentate Gyrus Neurons

“…In both studies, ϳ5-10% of potentiation in pEPSP slope was still observed at the end of recording. This is probably because the dose chosen for the present study was moderate because higher concentration of both inhibitors was known to produce cell toxicity (Lindenboim et al 1995;Wenzel and Cosma 1984). In another study, Huang and Kandel (1995) have similarly reported that dopamine D1/D5 receptor activation also produces a protein synthesis-dependent longlasting potentiation of hippocampal neurons.…”

Kardiotoxizität des 5-Fluorouracil - Klinische Relevanz bei palliativer Radiochemotherapie von malignen Kopf-Hals-Tumoren -

“…Durch In-vitro-Untersuchungen konnte von Wenzel und Cosma [16] Die klinischen Beschwerden sprechen in unterschiedlichem Ausmaû auf eine antianginöse Therapie an. Bei einem Teil der Patienten verschwindet die klinische Symptomatik und EKG-Veränderung nach Gabe von Nitroglycerin, b-Rezeptorenblockern und besonders Kalzium-Antagonisten und die Zystostatikatherapie kann fortgesetzt werden.…”

Absorption, distribution and excretion of3H-labeled cephaeline- and emetine-spiked ipecac syrup in rats

“…Emetine is a direct myotoxin which inhibits protein synthesis and disrupts mitochondrial oxidative phosphorylation 18). In animal experiments, emetine has been shown to cause cardiac toxicity as well 19,20). In the current study, high retention of 3H-EM was evident in most tissues, includingthe heart.…”

Corticotropin-Releasing Factor Produces a Protein Synthesis–Dependent Long-Lasting Potentiation in Dentate Gyrus Neurons

“…In both studies, ϳ5-10% of potentiation in pEPSP slope was still observed at the end of recording. This is probably because the dose chosen for the present study was moderate because higher concentration of both inhibitors was known to produce cell toxicity (Lindenboim et al 1995;Wenzel and Cosma 1984). In another study, Huang and Kandel (1995) have similarly reported that dopamine D1/D5 receptor activation also produces a protein synthesis-dependent longlasting potentiation of hippocampal neurons.…”

Kardiotoxizität des 5-Fluorouracil - Klinische Relevanz bei palliativer Radiochemotherapie von malignen Kopf-Hals-Tumoren -

“…Durch In-vitro-Untersuchungen konnte von Wenzel und Cosma [16] Die klinischen Beschwerden sprechen in unterschiedlichem Ausmaû auf eine antianginöse Therapie an. Bei einem Teil der Patienten verschwindet die klinische Symptomatik und EKG-Veränderung nach Gabe von Nitroglycerin, b-Rezeptorenblockern und besonders Kalzium-Antagonisten und die Zystostatikatherapie kann fortgesetzt werden.…”