A model of overall regulation of body fluids

SAPHIR: a physiome core model of body fluid homeostasis and blood pressure regulation

“…Certainly, one such problem is the regulation of arterial blood pressure, as was amply established by Guyton and his many collaborators, since their quantitative systems models led them to profoundly reorient our understanding of the causes of hypertension. This was our rationale for adopting the early Guyton et al (1972) model and its extension to acid-base regulation by Ikeda et al (1979) as the initial demonstrators for the core modelling environment. Obviously, ours is neither the first nor the last (re-)implementation of the Guyton models, which were not only implemented with a generic user interface (called MODSIM; see Montani et al 1989), but have also been usefully deployed in a number of contexts, including research on the physiological consequences of weightlessness in manned space flight (White et al 1991(White et al , 2003.…”

“…In Ikeda et al (1979), these were set against the data from the literature to show that the model behaviour agreed well with the experimental results pertaining to body fluid and acid-base disorders.…”

“…As with the M2SL model described above, we used the output from Guyton's in silico experiments (Guyton et al 1972) as benchmarks to validate the implementation of Guyton's 1972 circulatory model ('G72') The model of Ikeda et al (1979) was very clearly and completely described in the original paper. The model was illustrated with one block diagram (figure 4), defining the global structure and the links between the inputs and outputs of the blocks.…”

“…Rather than starting from scratch, two legacy integrated models have served as the starting point, namely the classic model of Guyton et al (1972), which focused on blood pressure regulation, and the model of Ikeda et al (1979), based on Guyton's models but extended to focus on the overall regulation of body fluids. We have functioning re-implementations of the Guyton et al and Ikeda et al models in FORTRAN, CCC, SIMULINK and also using the ODE solver BERKELEY MADONNA.…”

SAPHIR - a multi-scale, multi-resolution modeling environment targeting blood pressure regulation and fluid homeostasis

“…The core model includes basic descriptions of the heart, vasculature, intra-and extracellular spaces, lungs, kidneys, and muscles. Rather than starting from scratch, the core model is based on two legacy models that treated overall regulation of blood pressure (Guyton et al 1972) and fluid regulation (Ikeda et al 1979).…”