Abstract.We present a modified energy-principle based model of fatigue damage accumulation in high temperature alloys usually used in gas turbine engine under combined high cycle fatigue and low cycle fatigue (LCF/HCF) loading conditions. Our model is based on the energy principle which includes a modified approximation formula that describes fatigue crack origin depending on the relative amplitude of stress intensity in the ranges of both high-and lowcycle fatigue under non-isothermal loading. Functional dependence that presents the influence of HCF mechanisms on a fatigue life of our structural material is gradual and it has not breaks of the curve that yields a possibility to rewrite the equation of the S-N curve with taking into account combined cycle fatigue loading. We used the same number of parameters as the initial model. Note, that new parameter interpretation gives clear physical picture. The proposed model is verified by comparing the computed results with the experimental data for one high temperature alloy GH4133.