2012
DOI: 10.1371/journal.pone.0033544
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Abstract: Cancer stem cells (CSCs) are capable of continuous proliferation and self-renewal and are proposed to play significant roles in oncogenesis, tumor growth, metastasis and cancer recurrence. CSCs are considered derived from normal stem cells affected by the tumor microenvironment although the mechanism of development is not clear yet. In 2007, Yamanaka's group succeeded in generating Nanog mouse induced pluripotent stem (miPS) cells, in which green fluorescent protein (GFP) has been inserted into the 5′-untransl… Show more

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Cited by 105 publications
(164 citation statements)
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“…1D). Considering the recovery of tEVs from CM, this concentration is similar to that in the CM used for CSC-conversion (150~250 ng/mL) 16. Therefore, we used 100 ng/mL of tEVs as the optimal condition for conversion of CSCs.…”
Section: Resultsmentioning
confidence: 99%
“…1D). Considering the recovery of tEVs from CM, this concentration is similar to that in the CM used for CSC-conversion (150~250 ng/mL) 16. Therefore, we used 100 ng/mL of tEVs as the optimal condition for conversion of CSCs.…”
Section: Resultsmentioning
confidence: 99%
“…4). Several preceding studies have argued that some CSC properties, such as enhanced tumorigenicity, may be inducible (5)(6)(7). However, these reports did not show whether these cells have the ability to differentiate into specific types of cancer tissues.…”
Section: Introductionmentioning
confidence: 95%
“…Chen et al discovered that growing GFP-labeled mouse iPS cells in conditioned media from one of four murine carcinoma cells, or co-cultured with murine mammary carcinoma cells, led to the acquisition of cancer stem cell phenotypes, including the ability to grow in sphere culture and form undifferentiated carcinomas in vivo. 27 In any of the above scenarios, key signaling pathways used by stem cells to regulate self-renewal, proliferation and differentiation are interrupted or deregulated, and their activities culminate in the creation of a tumor initiating cell. The tumor initiating cell(s) can domain (NCID), translocates to the nucleus, where it functions as a transcriptional co-activator for proteins such as suppressor of hairless (SuH).…”
Section: Normal and Cancer Stem Cellsmentioning
confidence: 99%