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Cited by 1,106 publications
(988 citation statements)
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“…It has been proposed that fluid flow at the fracture gap may play an important role in fracture healing [14,25]. In our experimental setup, two effects of volume change can be assumed.…”
Section: Discussionmentioning
confidence: 99%
“…It has been proposed that fluid flow at the fracture gap may play an important role in fracture healing [14,25]. In our experimental setup, two effects of volume change can be assumed.…”
Section: Discussionmentioning
confidence: 99%
“…Theoretical models have been advanced suggesting that information regarding mechanical loading is perceived by bone cells through loading-induced oscillatory fluid flow (Kufahl and Saha, 1990;Weinbaum et al, 1994;Cowin et al, 1995), including the wall shear stress in the marrow compartment (Swan et al, 2003). These theoretical models also predict that bone cells are exposed to fluid induced shear stress that is on the order of 0.8 to 3 Pa in vivo (Weinbaum et al, 1994) (a paschal is force per area, where 1 Pa = N/m 2 ). Furthermore, it is certain that any flow of fluid (flow is characterized as dynes/cm 2 , or the amount of drag across an area) due to periodic loading of the tissue, as occurs with physical activity, results in a flow profile that is dynamic and oscillatory in nature.…”
Section: What Mechanical Factors Are Generated By Loading?mentioning
confidence: 99%
“…Following the treatments, cells were loaded with a 5 μM of Fluo‐4AM (ThermoFisher Scientific), a fluorescent Ca 2+ indicator for 45 min at 37°C to observe the cellular response to FSS. The cells were then subjected to 20 s of mechanical stimuli using a laminar fluid‐flow chamber to create a physiologically relevant FSS of 16 dynes/cm 2 , previously demonstrated to induce increases in [Ca 2+ ] i in vitro 30, 31, 32. Changes in [Ca 2+ ] i were monitored in real‐time using Leica AF6000 time‐lapse fluorescent microscope.…”
Section: Methodsmentioning
confidence: 99%