A Model for Steroid Effects in Herpes Keratitis

Herpes simplex virus 1 targets IRF7 via ICP0 to limit type I IFN induction

“…Long term topical and systemic use is associated with toxicity and adverse effects 67,68 . Similarly, topical steroids, although important therapeutic agents in the management of HSK are associated with risks such as the development of cataract and glaucoma [69][70][71] as well as facilitation of viral penetration into the cornea 72,73 . In advanced or recurrent cases, long-standing corneal inflammation can result in permanent scarring and loss of corneal transparency and is the major cause of decreased vision associated with HSK.…”

Herpes simplex virus 1 targets IRF7 via ICP0 to limit type I IFN induction

“…Long term topical and systemic use is associated with toxicity and adverse effects 67,68 . Similarly, topical steroids, although important therapeutic agents in the management of HSK are associated with risks such as the development of cataract and glaucoma [69][70][71] as well as facilitation of viral penetration into the cornea 72,73 . In advanced or recurrent cases, long-standing corneal inflammation can result in permanent scarring and loss of corneal transparency and is the major cause of decreased vision associated with HSK.…”

Incidence and Risk Factors of New Onset Endotheliitis After Cataract Surgery

“…30 Topical steroid use during HSV keratitis has been proven to be pernicious due to associated immunosuppression, facilitation of HSV transfer through corneal cell layers, and increasing cell susceptibility to HSV infection. [31][32][33] Previous studies have suggested endotheliitis may be related to intensive use of topical steroids causing local immunosuppression. 13,18 In this study, intensive use of steroids after surgery might have led to the development of endotheliitis following cataract surgery.…”

Failure of Inhibiting Corneal Graft Rejection in Rabbits by 5 α-Androstane-3,17-dione

“…Another potential danger of cortisol treatment exists in patients with herpes corneae, since corti sol is not only immunosuppressive but also antimetabolic. This latter effect reduces mu copolysaccharide synthesis in the corneal stroma \Bleckmann and Wollensak, 1975] thereby leading to an increased permeability of the stroma to particles of the size of vi rions [Robbins and Galin, 1975]. It would therefore be an advantage to use an immu nosuppressive drug without antimetabolic effect for preventing corneal graft rejection.…”

Herpes simplex virus 1 targets IRF7 via ICP0 to limit type I IFN induction

“…Long term topical and systemic use is associated with toxicity and adverse effects 67,68 . Similarly, topical steroids, although important therapeutic agents in the management of HSK are associated with risks such as the development of cataract and glaucoma [69][70][71] as well as facilitation of viral penetration into the cornea 72,73 . In advanced or recurrent cases, long-standing corneal inflammation can result in permanent scarring and loss of corneal transparency and is the major cause of decreased vision associated with HSK.…”

Incidence and Risk Factors of New Onset Endotheliitis After Cataract Surgery

“…30 Topical steroid use during HSV keratitis has been proven to be pernicious due to associated immunosuppression, facilitation of HSV transfer through corneal cell layers, and increasing cell susceptibility to HSV infection. [31][32][33] Previous studies have suggested endotheliitis may be related to intensive use of topical steroids causing local immunosuppression. 13,18 In this study, intensive use of steroids after surgery might have led to the development of endotheliitis following cataract surgery.…”

Failure of Inhibiting Corneal Graft Rejection in Rabbits by 5 α-Androstane-3,17-dione

“…Another potential danger of cortisol treatment exists in patients with herpes corneae, since corti sol is not only immunosuppressive but also antimetabolic. This latter effect reduces mu copolysaccharide synthesis in the corneal stroma \Bleckmann and Wollensak, 1975] thereby leading to an increased permeability of the stroma to particles of the size of vi rions [Robbins and Galin, 1975]. It would therefore be an advantage to use an immu nosuppressive drug without antimetabolic effect for preventing corneal graft rejection.…”

Herpes simplex virus 1 targets IRF7 via ICP0 to limit type I IFN induction

“…Long term topical and systemic use is associated with toxicity and adverse effects 67,68 . Similarly, topical steroids, although important therapeutic agents in the management of HSK are associated with risks such as the development of cataract and glaucoma [69][70][71] as well as facilitation of viral penetration into the cornea 72,73 . In advanced or recurrent cases, long-standing corneal inflammation can result in permanent scarring and loss of corneal transparency and is the major cause of decreased vision associated with HSK.…”

Incidence and Risk Factors of New Onset Endotheliitis After Cataract Surgery

“…30 Topical steroid use during HSV keratitis has been proven to be pernicious due to associated immunosuppression, facilitation of HSV transfer through corneal cell layers, and increasing cell susceptibility to HSV infection. [31][32][33] Previous studies have suggested endotheliitis may be related to intensive use of topical steroids causing local immunosuppression. 13,18 In this study, intensive use of steroids after surgery might have led to the development of endotheliitis following cataract surgery.…”

Failure of Inhibiting Corneal Graft Rejection in Rabbits by 5 α-Androstane-3,17-dione

“…Another potential danger of cortisol treatment exists in patients with herpes corneae, since corti sol is not only immunosuppressive but also antimetabolic. This latter effect reduces mu copolysaccharide synthesis in the corneal stroma \Bleckmann and Wollensak, 1975] thereby leading to an increased permeability of the stroma to particles of the size of vi rions [Robbins and Galin, 1975]. It would therefore be an advantage to use an immu nosuppressive drug without antimetabolic effect for preventing corneal graft rejection.…”