A mismatch between kinesthetic and visual perception in Parkinson's disease

Demirci, Mehmet; Grill, Stephen; McShane, Lisa M.; Hallett, Mark

doi:10.1002/ana.410410614

Cited by 178 publications

(110 citation statements)

References 23 publications

(8 reference statements)

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“…Numerous research findings suggest that a major source of the motor problems in PD is a dysfunctional sensorimotor integration. For example, the performance in tasks that rely on the integration of visual and proprioceptive stimuli are often impaired in PD patients [1,6]. This is consistent with results from animal studies that demonstrated that the basal ganglia respond to somatosensory, auditory and visual inputs with many neurons showing multimodal convergence [12].…”

Section: Discussionsupporting

confidence: 76%

The perception of passive motion in Parkinson's disease

et al. 2007

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The perception of limb motion is a kinaesthetic property that is essential for voluntary motor control. This study examined the ability of patients with Parkinson's disease (PD) to detect the velocity of a passively moved limb. Eight patients with mild to moderate PD and eight age-matched healthy controls participated. They placed their forearm on a padded splint of a passive motion apparatus, which horizontally extended or flexed the elbow joint at velocities between 1.65 and 0.075 degrees /s (in steps of 0.15 degrees /s). Passive movement persisted until subjects detected arm motion and pressed a trigger held in the hand of their non-tested arm. Time until detection and associated arm displacement were recorded and subsequently adjusted for each subject's reaction time. We found that PD patients needed significantly larger limb displacements before they could judge the presence of passive motion. With decreasing passive motion velocity the detection time increased exponentially in both groups. Yet, the mean detection times of the PD group were 92-166% higher than in the control group for each of the 12 tested velocity conditions. Five of the eight patients were on Parkinsonian medication when tested. Yet, the degree of impairment in the PD group did not correlate significantly with the patients' levodopa equivalent dosage. Our results demonstrate that PD patients were impaired in the detection of passive forearm movements. This study complements a growing body of evidence indicating that various aspects of kinaesthesis (position sense, weight perception, passive motion sense) are affected even at early stages of PD. The impaired processing of proprioceptive signals likely contributes to motor symptoms in PD.

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Section: Discussionsupporting

confidence: 76%

The perception of passive motion in Parkinson's disease

et al. 2007

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“…[1][2][3][4][5] Our results show a dysfunction in the treatment of proprioceptive information by the neurons of the SMA in the parkinsonian situation, which apparently are linked more to a surfeit of inappropriate information than to a decrease in the quantity of information received. Cortical neurons may receive inputs of a misleading complexity or themselves may be incapable of efficiently treating the information they receive.…”

Section: Discussionmentioning

confidence: 81%

Disruption of the proprioceptive mapping in the medial wall of parkinsonian monkeys

Escola¹,

Michelet²,

Douillard³

et al. 2002

Annals of Neurology

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Parkinsonian patients present an impairment of proprioceptor-guided movement that could imply abnormal processing in the frontal mesial cortex. To test this hypothesis, we compared neuronal response to joint displacement in the supplementary and presupplementary motor areas of two monkeys, before and after the progressive establishment of an 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonian syndrome. After MPTP administration, neurons were activated by the passive movement of numerous joints in various directions and no longer simply by one or two joints in one direction. This impairment of the focused selection of proprioceptive inputs, imputable to dopamine depletion, could impede motor planning and thus contribute to akinesia.

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“…The amplified motor responses to visual inputs in most of these studies parallel those in our task. It has been suggested that over-weighting of visual information might be a learned response to poor kinaesthetic feedback (Azulay, 2006, Demirci et al, 1997. Poliakoff et al (2007) found a speeding effect for action-relevant visual information in HC but not PD participants.…”

Section: Visual Control Of Walking In Pdmentioning

confidence: 99%

Insights into the neural control of locomotion from walking through doorways in Parkinson's disease

et al. 2010

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. (2010) 'Insights into the neural control of locomotion from walking through doorways in Parkinson's disease. ', Neuropsychologia., 48 (9). pp. 2750-2757. Further information on publisher's website:http://dx.doi.org/10. 1016/j.neuropsychologia.2010.05.022 Publisher's copyright statement: NOTICE: this is the author's version of a work that was accepted for publication in Neuropsychologia. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reected in this document. Changes may have been made to this work since it was submitted for publication. A denitive version was subsequently published in Neuropsychologia, 48, 9, July 2010, 10.1016/j.neuropsychologia.2010.05.022. Additional information:Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-prot purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details. behaviour to investigate the visual control of locomotion and the role of the basal ganglia in this system. We use a variable-width doorway to measure the scaling of motor output to visual input specifying door width. By measuring walking behaviour as participants passed through the doorway, we show that both PD and healthy control participants scaled their locomotor outputs to door width. Both groups reacted to narrower doors by walking more slowly with shorter strides. However, the changes were greater in the PD group, where walking speed dramatically decreased while approaching the doorway. Such a pattern could help explain why doorways cause freezing episodes in PD. Neither explicit perceptual judgements of door width, nor performance on motor tasks, predicted the door behaviour.On the basis of these findings, we propose that PD is associated with a visuomotor disturbance, such that responses to action-relevant visual information are exaggerated. In the PD group, dopaminergic medications improved many baseline gait variables but did not affect their sensitivity to door width, suggesting that this visuomotor effect is not mediated by the basal ganglia. This hypothesis provides a novel framework for interpreting a variety of results with PD patients.

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A mismatch between kinesthetic and visual perception in Parkinson's disease

Cited by 178 publications

References 23 publications

The perception of passive motion in Parkinson's disease

The perception of passive motion in Parkinson's disease

Disruption of the proprioceptive mapping in the medial wall of parkinsonian monkeys

Insights into the neural control of locomotion from walking through doorways in Parkinson's disease

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