A Miniature Compliance Monitor for Eyedrop Medication

Effect of Changing Medication Regimens in Glaucoma Patients

“…A review of published studies on com pliance with antiglaucoma medications indi cates that patient compliance with these chronic treatments is not exceptionally high [2], In studies testing patient compliance using electronic monitors, Siegel et al [3] and Kass et al [10] found a compliance rate of 60-70% in patients taking timolol twice daily who were unaware that their compliance was being monitored. Perhaps in the present study, patients were more aware of the sever ity of their disease and of the careful moni toring of their IOP and visit schedules, and therefore, compliance increased.…”

Effect of Changing Medication Regimens in Glaucoma Patients

“…A review of published studies on com pliance with antiglaucoma medications indi cates that patient compliance with these chronic treatments is not exceptionally high [2], In studies testing patient compliance using electronic monitors, Siegel et al [3] and Kass et al [10] found a compliance rate of 60-70% in patients taking timolol twice daily who were unaware that their compliance was being monitored. Perhaps in the present study, patients were more aware of the sever ity of their disease and of the careful moni toring of their IOP and visit schedules, and therefore, compliance increased.…”

Role of Patient Compliance in Clinical Pharmacokinetics

“…Research has been catalysed by 2 factors. One has been the introduction in 1986 to 1987 of objective measures of compliance by chemical marker [6,7] and electronic monitoring [8][9][10][11] means. The second factor has been a strong focus on clinical and pharmacometric consequences of variable compliance, [10,[12][13][14][15][16][17][18][19] which was conspicuously lacking in prior years.…”

“…Thus, any meaningful analysis of therapeutic failure requires data on compliance not only for scientific reasons, but also because noncompliance is a principal reason for therapeutic failure, [4,5,9] and usually evades clinical detection)5, 10,25] Given the often high failure rates of prescription drug therapy in various types of ambulatory care, no serious programme of quality assurance or quality management can ignore patient compliance, Drugs in the same pharmacological class may differ in their abilities to maintain pharmacological and/or therapeutic action in the face of omitted doses, Drugs with this attribute, often called 'forgiveness' , [29,30] may be useful for the treatment of patients who are unable to maintain a satisfactory level of compliance. The level of forgi veness of an individual drug has only recently begun to be studied and developed as a point of differentiation among otherwise indistinguishable agents)31] As one of many attributes of a drug, the value of forgiveness must be judged in the context of its pharmacological activity.…”

Patient Preferences for Eye Drop Characteristics

“…We found that 85% of subjects reported never or almost never forgetting to take their eye drops, whereas Kass et al 13 found that a much higher proportion of patients fail to consistently use their eye drops when assessed with a compliance monitor. Although the search to develop eye drops that are convenient to use with minimal adverse effects is important, it is justified only if it results in better patient compliance with therapy.…”

Effect of Changing Medication Regimens in Glaucoma Patients

“…A review of published studies on com pliance with antiglaucoma medications indi cates that patient compliance with these chronic treatments is not exceptionally high [2], In studies testing patient compliance using electronic monitors, Siegel et al [3] and Kass et al [10] found a compliance rate of 60-70% in patients taking timolol twice daily who were unaware that their compliance was being monitored. Perhaps in the present study, patients were more aware of the sever ity of their disease and of the careful moni toring of their IOP and visit schedules, and therefore, compliance increased.…”

Role of Patient Compliance in Clinical Pharmacokinetics

“…Research has been catalysed by 2 factors. One has been the introduction in 1986 to 1987 of objective measures of compliance by chemical marker [6,7] and electronic monitoring [8][9][10][11] means. The second factor has been a strong focus on clinical and pharmacometric consequences of variable compliance, [10,[12][13][14][15][16][17][18][19] which was conspicuously lacking in prior years.…”

“…Thus, any meaningful analysis of therapeutic failure requires data on compliance not only for scientific reasons, but also because noncompliance is a principal reason for therapeutic failure, [4,5,9] and usually evades clinical detection)5, 10,25] Given the often high failure rates of prescription drug therapy in various types of ambulatory care, no serious programme of quality assurance or quality management can ignore patient compliance, Drugs in the same pharmacological class may differ in their abilities to maintain pharmacological and/or therapeutic action in the face of omitted doses, Drugs with this attribute, often called 'forgiveness' , [29,30] may be useful for the treatment of patients who are unable to maintain a satisfactory level of compliance. The level of forgi veness of an individual drug has only recently begun to be studied and developed as a point of differentiation among otherwise indistinguishable agents)31] As one of many attributes of a drug, the value of forgiveness must be judged in the context of its pharmacological activity.…”

Patient Preferences for Eye Drop Characteristics

“…We found that 85% of subjects reported never or almost never forgetting to take their eye drops, whereas Kass et al 13 found that a much higher proportion of patients fail to consistently use their eye drops when assessed with a compliance monitor. Although the search to develop eye drops that are convenient to use with minimal adverse effects is important, it is justified only if it results in better patient compliance with therapy.…”

Effect of Changing Medication Regimens in Glaucoma Patients

“…A review of published studies on com pliance with antiglaucoma medications indi cates that patient compliance with these chronic treatments is not exceptionally high [2], In studies testing patient compliance using electronic monitors, Siegel et al [3] and Kass et al [10] found a compliance rate of 60-70% in patients taking timolol twice daily who were unaware that their compliance was being monitored. Perhaps in the present study, patients were more aware of the sever ity of their disease and of the careful moni toring of their IOP and visit schedules, and therefore, compliance increased.…”

Role of Patient Compliance in Clinical Pharmacokinetics

“…Research has been catalysed by 2 factors. One has been the introduction in 1986 to 1987 of objective measures of compliance by chemical marker [6,7] and electronic monitoring [8][9][10][11] means. The second factor has been a strong focus on clinical and pharmacometric consequences of variable compliance, [10,[12][13][14][15][16][17][18][19] which was conspicuously lacking in prior years.…”

“…Thus, any meaningful analysis of therapeutic failure requires data on compliance not only for scientific reasons, but also because noncompliance is a principal reason for therapeutic failure, [4,5,9] and usually evades clinical detection)5, 10,25] Given the often high failure rates of prescription drug therapy in various types of ambulatory care, no serious programme of quality assurance or quality management can ignore patient compliance, Drugs in the same pharmacological class may differ in their abilities to maintain pharmacological and/or therapeutic action in the face of omitted doses, Drugs with this attribute, often called 'forgiveness' , [29,30] may be useful for the treatment of patients who are unable to maintain a satisfactory level of compliance. The level of forgi veness of an individual drug has only recently begun to be studied and developed as a point of differentiation among otherwise indistinguishable agents)31] As one of many attributes of a drug, the value of forgiveness must be judged in the context of its pharmacological activity.…”

Patient Preferences for Eye Drop Characteristics

“…We found that 85% of subjects reported never or almost never forgetting to take their eye drops, whereas Kass et al 13 found that a much higher proportion of patients fail to consistently use their eye drops when assessed with a compliance monitor. Although the search to develop eye drops that are convenient to use with minimal adverse effects is important, it is justified only if it results in better patient compliance with therapy.…”