A Mini-Review on Nano Technology in the Tumour Targeting Strategies: Drug Delivery to Cancer Cells

Abstract

Background: Recently, the application of cancer nanotechnology-based drug delivery to cancer cells has arisen as an important method to resolve multiple molecular, biophysical and biochemical obstacles, which the body is preparing to resist against the productive implementation of chemotherapeutic medications. Drug delivery technologies focused on nanoparticles which have resolved some of the drawbacks of conventional chemotherapy as, decreased drug viscosity, chemo-resistance, precise malignity, limited medicative measures with low oral bioactivity. Due to their adjustable size and surface properties, the half-life period of a drug can be increased in the bloodstream. Objective: The aim of the current study is collecting and documenting the data available on the drug delivery system for anticancer drugs. The present study includes some of the drug carriers like liposomes, carbon dots, micelles, carbon nanotubes, magnetic nanoparticles, etc. Methods: To write this review, an exhaustive literature survey was carried out using, relevant work published in various SCI, Scopus, and non-SCI indexed journals. The different search engines used to download the research/review papers are Google search, PubMed, Science Direct, Google Scholar, Scientific Information Database and Research Gate, etc. Results: Nanotechnology offers better pharmacokinetics, reduces the systematic toxicities related to the chemotherapies and a better route of drug administration. In the analysis, we critically highlight recent studies on carcinoma-fighting nanotechnology. Conclusion: In the present study, the different kinds of nano-based drug delivery systems have been discussed along with their characteristic features, the encapsulation of anticancer agents into different types of nanometre-sized vehicles and their general mechanism.

Recent advances in lipid-engineered multifunctional nanophytomedicines for cancer targeting

“…Apart from the polymeric nanoparticles, other nanotechnology driven drug delivery systems were also developed like nanostructured lipidic carriers, solid lipid nanoparticles, dendrimers, polymeric micelles, liposomes, nanoemulsion, and many more, for the anticancer delivery via oral route. Apart from this, oral route has been blessed with various advantages like self-administration by patients, ease of administration and no monitoring required for chemotherapeutic and area of interest for the formulation scientist in the oncology area [83,84].…”

Nanocarriers for the delivery of antibiotics into cells against intracellular bacterial infection

“…In recent years, the effective delivery of antibiotics into cells based on nanotechnology for the enhancement of intracellular antibacterial activity has become a hot spot in anti-intracellular bacterial infection research. [12][13][14] Although there are many reviews of nanocarriers, most of the nanocarriers are used to deliver anti-tumor drugs, 15 genes 16 or CRISPR gene editing systems. 17 And those reported nanocarriers used to deliver antibiotics mainly focused on local delivery to improve drug concentration at the infection site 18 and overcoming bacterial envelope barrier to promote bacterial internalization of antibiotic.…”

Acid-Sensitive Nanoparticles Based on Molybdenum Disulfide for Photothermal-Chemo Therapy

“…More than 100 types of cancer have been found, each of which requires targeted treatment. Cancer treatment methods are mainly divided into three categories: surgery, chemotherapy, and radiotherapy. − These traditional treatment methods have not met the needs of modern tumor treatment because the treatment cycle of chemotherapy is long, and radiotherapy causes hair loss. − Consequently, there is a need to find new antitumor treatment methods to replace or overcome the disadvantages of traditional treatment methods.…”