A Mild Transient Decrease of Peripheral Red Blood Cell Counts Induced by a Suprapharmacological Dose of Pegylated Human Megakaryocyte Growth and Development Factor in Rats
Abstract:Previous studies have shown that pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) at suprapharmacological dose induces a mild transient decrease of red blood cell counts according to thrombopoiesis in normal mice. To unravel the mechanism underlying this mild transient decrease of red blood cells, we have studied the effect of PEG-rHuMGDF on the circulating plasma and blood volume, and the serum biochemical parameters of anaemia and splenectomy. Also, we have performed hist… Show more
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