A microfluidic distributor combining minimal volume, minimal dispersion and minimal sensitivity to clogging

Numerical study of bacteria removal from microalgae solution using an asymmetric contraction-expansion microfluidic device: A parametric analysis approach

“…In this regard, feed liquids have to be equally distributed at the inlets of the parallel Asym-CEMCs. Flow distributors for microfluidic systems are being developed to deal with the scale-up challenge of these devices [ [45] , [46] , [47] ].…”

Towards spatial comprehensive three-dimensional liquid chromatography: A tutorial review

“…When chip prototyping is the limiting factor and local imperfections (constrictions blocking a small segment of a microchannel) exist, a 'hybrid' flow distributor design can be utilized. This design is based on bifurcations but also integrates mixing zones after several levels of bifurcations where different parallel zone flow paths come again in direct fluidic contact [34].…”

“…Such distributor 13 was initially developed for electro-driven separations, but the same concept can be applied to distribute flow in pressure-driven mode. The designs of both bifurcating and radiallyinterconnected flow distributors were studied by the Desmet group using computational fluid dynamics (CFD)[31][32][33][34]. Vangelooven et al designed radially-interconnected flow distributors with diamond-shaped pillars having their longest dimension oriented perpendicular to the flow direction[31].…”

Engineering solutions for flow control in microfluidic devices for spatial multi-dimensional liquid chromatography

“…To generate a homogenous flow across parallel ( 2 D) channels, flow distributors were developed based on prototypes for 1D-LC by Regnier et al [14] and Desmet et al [15]. Based on insights obtained with computational fluid dynamics simulations and executing on-chip flow experiments, fractal bifurcating flow distributor designs were optimized [16,17]. Also, a fractal 3D flow distributor was developed to distribute a flow across 256 parallel channels filling the 3D space [18].…”