half-life compared to tenofovir in plasma, allowing a broader picture of adherence within a 2-week span. The levels of TFV-DP observed in their 2 coinfected patients who had detectable HBV replication, despite long periods of plasma HIV-RNA suppression and TDF-containing antiretroviral therapy, revealed that TDF was not consistently taken before the study visit. From their experience, suboptimal treatment adherence would be the most probable underlying cause for HBV persistence. Because this technique require…
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