A Memory Assessment Technique for Use in Geriatric Psychopharmacology: Drug Efficacy Trial with Naftidrofuryl

Branconnier, Roland J.; Cole, Jonathan O.

doi:10.1111/j.1532-5415.1977.tb00291.x

Cited by 11 publications

(1 citation statement)

References 10 publications

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“…The clinical trials in chronic cerebral insufficiency (Adriaensen, 1974;Bargheon, 1975;Bouwier et aI., 1974;Branconnier and Cole, 1977;Brodie, 1977;Cox, 1975;Gerin, 1974;Judge and Urquhart, 1972;Robinson, 1972;Trouillas, 1977) were based on a mean sample size of 52 subjects and a follow-up period of 2 to 3 months, with a mean dosage of 300mg tid. The diagnostic and admission criteria were invariably iII-defined, and drop-outs were as high as 1 in 3 in 2 studies (Adriaensen, 1974;Judge and Urquhart, 1972).…”

Section: Clinical Studiesmentioning

confidence: 99%

???Cerebroactive??? Drugs Clinical Pharmacology and Therapeutic Role in Cerebrovascular Disorders

Spagnoli

Tognoni

1983

Drugs

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While their importance in the market-place is steadily increasing in developed (mainly continental Europe) and even in developing countries, compounds included in the broad category of 'cerebroactive' drugs hardly rate a mention in reference pharmacology and therapeutics textbooks. It is an undeniable fact, however, that the principal users or targets of this drug class, mainly elderly people, represent an increasingly worrying problem, with their often puzzling cohort of ill-definable and even less predictable neurological and mental symptoms. The combination of the above factors cannot but produce a rather confused situation, in which the pressure to treat and the adherence to scientifically rigorous assessment are likely to prevail alternately, on a purely casual basis. This review aims to provide sound methodological guidelines for assessment of 'cerebroactive' drugs in a not always easily accessible literature. It covers firstly the general problems of stroke, dementia and 'common symptoms' of the elderly, and then looks in detail at those compounds which have to date attracted most attention (ergot derivatives, cinnarizine, flunarizine, vincamine, eburnamonine, naftidrofuryl, oxpentifylline, piracetam and citicoline), as well as those which are currently considered investigational (choline and lecithin). The pharmacology and available clinical studies of each drug are examined. No therapeutic indication can be derived from the available evidence, as the few positive results do not go beyond random improvement of symptoms. More fundamentally, the lines of research which need to be pursued most intensively relate to better preliminary definition of diagnostic and prognostic criteria and, with the establishment of adequate testing tools for the assessment of behaviour and neuropsychological performance, those basal conditions which are modified 'naturally' or by drugs.

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Section: Clinical Studiesmentioning

confidence: 99%

???Cerebroactive??? Drugs Clinical Pharmacology and Therapeutic Role in Cerebrovascular Disorders

Spagnoli

Tognoni

1983

Drugs

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Naftidrofuryl for dementia

Song

Zeng

et al. 2011

Cochrane Database of Systematic Reviews

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ACTH 4-10 in the amelioration of neuropsychological symptomatology associated with senile organic brain syndrome

1979

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Eighteen male and female volunteers over the age of sixty who exhibited mild senile organic brain syndrome were administered ACTH 4-10 (Org OI 63) (30 mg, s.c.) or saline in a 2 X 2 Latin square design. Subjects experienced a reduction in depression and confusion and an increase in vigor. This evidence of an increase in vigor was supported behaviorally by a delay in the onset of increased latency in reaction time. Data also indicated that retrieval from memory may be enhanced by this compound. The electroencephalogram evinced a shift to lower frequencies under ACTH 4-10, but this effect was primarily noted in the females who received drug followed by placebo. These effects of ACTH 4-10 are intriguing and suggest that further work in this area should be encouraged.

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A Memory Assessment Technique for Use in Geriatric Psychopharmacology: Drug Efficacy Trial with Naftidrofuryl

Cited by 11 publications

References 10 publications

???Cerebroactive??? Drugs Clinical Pharmacology and Therapeutic Role in Cerebrovascular Disorders

???Cerebroactive??? Drugs Clinical Pharmacology and Therapeutic Role in Cerebrovascular Disorders

Naftidrofuryl for dementia

ACTH 4-10 in the amelioration of neuropsychological symptomatology associated with senile organic brain syndrome

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