A luminal unfolding microneedle injector for oral delivery of macromolecules

Abramson, Alex; Caffarel–Salvador, Ester; Soares, Vance; Minahan, Daniel; Tian, Ryan Yu; Lu, Xianping; Dellal, David; Gao, Yuan; Kim, Soyoung; Wainer, Jacob; Collins, Joy; Tamang, Siddartha; Hayward, Alison; Yoshitake, Tadayuki; Lee, Hsiang‐Chieh; Fujimoto, James G.; Fels, Johannes; Frederiksen, Morten Revsgaard; Rahbek, Ulrik Lytt; Roxhed, Niclas; Langer, Robert

doi:10.1038/s41591-019-0598-9

Cited by 189 publications

(161 citation statements)

References 44 publications

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“…For example, robotic devices in the centimeter range have been widely used for gastrointestinal assisted delivery, where the robot is used to pierce tissue or collect samples. [269,270] The miniaturization of robotic devices could enhance our ability to access even more remote locations inside the body. Most of the literature on tissue penetration is composed of externally powered micro/nanorobots, as external fields are capable of penetrating thick biological tissue.…”

Section: Tissue Penetrationmentioning

confidence: 99%

Medical Micro/Nanorobots in Precision Medicine

et al. 2020

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Advances in medical robots promise to improve modern medicine and the quality of life. Miniaturization of these robotic platforms has led to numerous applications that leverages precision medicine. In this review, the current trends of medical micro and nanorobotics for therapy, surgery, diagnosis, and medical imaging are discussed. The use of micro and nanorobots in precision medicine still faces technical, regulatory, and market challenges for their widespread use in clinical settings. Nevertheless, recent translations from proof of concept to in vivo studies demonstrate their potential toward precision medicine.

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Section: Tissue Penetrationmentioning

confidence: 99%

Medical Micro/Nanorobots in Precision Medicine

et al. 2020

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“…To increase the release of biomolecules from the intestine into the bloodstream, Abramson et al developed a capsule named LUMI for the oral administration of various biomacromolecule drugs, using insulin as the potential target drug [206]. The device consisted of three degradable arms with drug-loaded microneedles packed into a capsule that was 9 mm in diameter and 30 mm in length.…”

Section: Intestines and Colon Deliverymentioning

confidence: 99%

Micro and nanoscale technologies in oral drug delivery

Ahadian

Finbloom

Mofidfar

et al. 2020

Advanced Drug Delivery Reviews

152

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Micro and nanocarriers Micro and nanoscale technologies Oral drug delivery Tissue models Oral administration is a pillar of the pharmaceutical industry and yet it remains challenging to administer hydrophilic therapeutics by the oral route. Smart and controlled oral drug delivery could bypass the physiological barriers that limit the oral delivery of these therapeutics. Micro-and nanoscale technologies, with an unprecedented ability to create, control, and measure micro-or nanoenvironments, have found tremendous applications in biology and medicine. In particular, significant advances have been made in using these technologies for oral drug delivery. In this review, we briefly describe biological barriers to oral drug delivery and micro and nanoscale fabrication technologies. Micro and nanoscale drug carriers fabricated using these technologies, including bioadhesives, microparticles, micropatches, and nanoparticles, are described. Other applications of micro and nanoscale technologies are discussed, including fabrication of devices and tissue engineering models to precisely control or assess oral drug delivery in vivo and in vitro, respectively. Strategies to advance translation of micro and nanotechnologies into clinical trials for oral drug delivery are mentioned. Finally, challenges and future prospects on further integration of micro and nanoscale technologies with oral drug delivery systems are highlighted.

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“…Abramson et al also took advantage of the microneedle concept to design a Luminal Unfolding Microneedle Injection (LUMI) device on top of a compressed spring [83]. When the device enters the pHneutral small intestine, a polymer that was immobilizing the spring gets dissolved, which leads to ejection of the device (Fig.…”

Section: Macrodevices For Gi Manipulation (Mm Scale): Drug Deliverymentioning

confidence: 99%

Orally ingestible medical devices for gut engineering

Mandsberg

Christfort

Kamguyan

et al. 2020

Advanced Drug Delivery Reviews

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Orally ingestible medical devices provide significant advancement for diagnosis and treatment of gastrointestinal (GI) tract-related conditions. From micro-to macroscale devices, with designs ranging from very simple to complex, these medical devices can be used for site-directed drug delivery in the GI tract, real-time imaging and sensing of gut biomarkers. Equipped with uni-direction release, or self-propulsion, or origami design, these microdevices are breaking the barriers associated with drug delivery, including biologics, across the GI tract. Further, on-board microelectronics allow imaging and sensing of gut tissue and biomarkers, providing a more comprehensive understanding of underlying pathophysiological conditions. We provide an overview of recent advances in orally ingestible medical devices towards drug delivery, imaging and sensing. Challenges associated with gut microenvironment, together with various activation/actuation modalities of medical devices for micromanipulation of the gut are discussed. We have critically examined the relationship between materials-device design-pharmacological responses with respect to existing regulatory guidelines and provided a clear roadmap for the future.

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A luminal unfolding microneedle injector for oral delivery of macromolecules

Cited by 189 publications

References 44 publications

Medical Micro/Nanorobots in Precision Medicine

Medical Micro/Nanorobots in Precision Medicine

Micro and nanoscale technologies in oral drug delivery

Orally ingestible medical devices for gut engineering

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