A low-swelling hydrogel as a multirole sealant for efficient dural defect sealing and prevention of postoperative adhesion
Xueliang Cheng,
Zhen Zhang,
Hui Ren
et al.
Abstract:Dural defects and subsequent complications, including cerebrospinal fluid (CSF) leakage, are common in spine surgery and neurosurgery, and existing clinical treatments are still unsatisfactory. In this study, a tissue-adhesive and low-swelling hydrogel sealant comprising gelatin and o-phthalaldehyde (OPA)-terminated 4-armed poly(ethylene glycol) (4aPEG-OPA) is developed via the OPA/amine condensation reaction. The hydrogel shows an adhesive strength of 79.9 ± 12.0 kPa on porcine casing and a burst pressure of … Show more
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