A local water molecular-heating strategy for near-infrared long-lifetime imaging-guided photothermal therapy of glioblastoma

Abstract

Owing to the strong absorption of water in the near-infrared (NIR) region near 1.0 μm, this wavelength is considered unsuitable as an imaging and analytical signal in biological environments. However, 1.0 μm NIR can be converted into heat and used as a local water-molecular heating strategy for the photothermal therapy of biological tissues. Herein, we describe a Nd-Yb co-doped nanomaterial (water-heating nanoparticles (NPs)) as strong 1.0 μm emissive NPs to target the absorption band of water. Furthermore, introducing Tm ions into the water-heating NPs improve the NIR lifetime, enabling the development of a NIR imaging-guided water-heating probe (water-heating NIR NPs). In the glioblastoma multiforme male mouse model, tumor-targeted water-heating NIR NPs reduce the tumor volume by 78.9% in the presence of high-resolution intracranial NIR long-lifetime imaging. Hence, water-heating NIR NPs can be used as a promising nanomaterial for imaging and photothermal ablation in deep-tissue-bearing tumor therapy.

Ultrafast and highly selective gold recovery with high capture capacity from electronic waste by upconversion of a silsesquioxane-based hybrid luminescent aerogel

“…Upconversion materials have attracted much attention because they can improve radiation harvesting in energy devices and photocatalytic reactors. 37–41 Under 980 nm NIR laser irradiation, CZ-B-DCM, PCS-CZ-B-DCM, and PCSs@chitosan can convert the NIR light to visible light at ∼601, 558 and 557 nm, respectively, which will enhance the photocatalytic activity of these materials (Fig. 3A).…”

High spatial-resolved heat manipulating membrane heterogeneity alters cellular migration and signaling

“…The localized photothermal effect of plasmonic nanoparticles has been widely used as noninvasive therapy for cancers ( 44 – 48 ). Thereby, although the NIR laser-induced solution temperature rise is only up to 42 °C, a relatively low temperature compared with that in photothermal therapy, we still assessed the cell viabilities after nanoheater anchoring and NIR illumination.…”

Nanoarchitectured conjugates targeting angiogenesis: investigating heparin-taurocholate acid conjugates (LHT7) as an advanced anti-angiogenic therapy for brain tumor treatment

“…During tumorigenesis, explosive induction of abnormal angiogenesis occurs when the volume of the tumor reaches 1 mm 3 [ 26 ], and the tight junction integrity of the blood–brain barrier is compromised by both tumor-induced pressure and factors secreted from the tumor [ 27 – 31 ]. To evaluate the potential of LHT7 to reach the tumor site via disrupted tight junctions, we first investigated the presence of an enhanced permeability and retention (EPR) effect in an established orthotopic glioblastoma xenograft mouse model.…”