A lipidomic concept in infectious diseases

Koriem, Khaled M. M.

doi:10.1016/j.apjtb.2016.12.010

Cited by 15 publications

(5 citation statements)

References 54 publications

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“…Taking into account the fact that viral, bacterial, or parasitic infections are usually accompanied by oxidative stress, the increased level of ROS promotes metabolism of lipids in the cells/organism of the host, whose metabolites are considered mediators of inflammation (Pohanka, 2013;Koriem, 2017). Lipid metabolism is controlled by ROS and/or enzymes, mainly phospholipases, cyclooxygenases (COXs), and lipoxygenases (LOXs), the activity of which is increased under oxidative stress (Ayala et al, 2014).…”

Section: Lipid Metabolism In Infectionsmentioning

confidence: 99%

Redox Imbalance and Its Metabolic Consequences in Tick-Borne Diseases

Groth

Skrzydlewska

Dobrzyńska

et al. 2022

Front. Cell. Infect. Microbiol.

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One of the growing global health problems are vector-borne diseases, including tick-borne diseases. The most common tick-borne diseases include Lyme disease, tick-borne encephalitis, human granulocytic anaplasmosis, and babesiosis. Taking into account the metabolic effects in the patient’s body, tick-borne diseases are a significant problem from an epidemiological and clinical point of view. Inflammation and oxidative stress are key elements in the pathogenesis of infectious diseases, including tick-borne diseases. In consequence, this leads to oxidative modifications of the structure and function of phospholipids and proteins and results in qualitative and quantitative changes at the level of lipid mediators arising in both reactive oxygen species (ROS) and ROS enzyme–dependent reactions. These types of metabolic modifications affect the functioning of the cells and the host organism. Therefore, links between the severity of the disease state and redox imbalance and the level of phospholipid metabolites are being searched, hoping to find unambiguous diagnostic biomarkers. Assessment of molecular effects of oxidative stress may also enable the monitoring of the disease process and treatment efficacy.

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Section: Lipid Metabolism In Infectionsmentioning

confidence: 99%

Redox Imbalance and Its Metabolic Consequences in Tick-Borne Diseases

Groth

Skrzydlewska

Dobrzyńska

et al. 2022

Front. Cell. Infect. Microbiol.

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“…122 Bacteriainduced infectious disease, as a growing global health problem, is one of the leading causes of human death worldwide. 123 Antibiotics are the mainstay of traditional antimicrobial treatments, but their excessive and even abusive use has made the issue of bacterial resistance more critically. About one million people die of infections caused by drug-resistant bacteria every year in the world, with an annual growth rate of 32%.…”

Section: Antibacterial Therapymentioning

confidence: 99%

“…Bacterial infection refers to a series of pathological changes caused by bacteria invading the host, multiplying, and interacting with the body 122 . Bacteria‐induced infectious disease, as a growing global health problem, is one of the leading causes of human death worldwide 123 . Antibiotics are the mainstay of traditional antimicrobial treatments, but their excessive and even abusive use has made the issue of bacterial resistance more critically.…”

Section: Enzyodynamic Therapy (Edt) For Versatile Disease Treatmentsmentioning

confidence: 99%

Enzyodynamic therapy at nanoscale

Wang,

Song,

Huang

et al. 2023

MedComm – Biomaterials and Applications

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Artificial enzymes featuring the desirable catalytic activity built on nanomaterials are known as nanozymes. Compared with the natural counterparts, nanozymes have demonstrated distinct characteristics including cost‐effectiveness, ease of preparation, high stability, and excellent recycling efficiency. With the rapid innovation of nanoscience and technology, a growing number of nanozymes have been deeply applied in disease prevention, diagnosis, and treatment. In addition, a multimodal platform for effectively interacting with complicated biologic settings has also been achieved by the inherent nanomaterial and dynamic features of nanozymes, which goes beyond simply serving as an enzyme substitute. In this review, we systematically discuss and highlight the classification and catalytic mechanism of nanozymes, regulation of nanozyme activity as well as the research progresses of nanozyme‐enabled/augmented enzyodynamic therapy in treating cancer based on producing and eliminating reactive oxygen species, bacterial infection, inflammation, neurodegeneration, and radiation‐induced tissue damage. Furthermore, the current challenges and future development direction of nanozymes in enzyodynamic disease therapy have been outlined and outlooked. It is highly anticipated that this review will be of guiding significance for better understanding the physiochemical properties and biological effect of nanozymes and the corresponding emerging enzyodynamic disease therapeutics.

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“…The lipidome or lipidomic is one of the omics science applies in modern biology[ 3 ]. There are a tight correlation between lipidomic, metabolomics, genomic and proteomic especially in protective and therapeutic studies[ 4 - 6 ]. Figure 1 explores different types of omics.…”

Section: Introductionmentioning

confidence: 99%

A lipidomic concept in infectious diseases

Cited by 15 publications

References 54 publications

Redox Imbalance and Its Metabolic Consequences in Tick-Borne Diseases

Redox Imbalance and Its Metabolic Consequences in Tick-Borne Diseases

Enzyodynamic therapy at nanoscale

Lipidome is lipids regulator in gastrointestinal tract and it is a life collar in COVID-19: A review

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