A light and scanning electron microscope study of the albino rat ileum after partial obstruction

Mahdy, Tarek; Mohamed, Gamal A.; Elhawary, Adel

doi:10.1016/j.aanat.2008.07.009

Cited by 3 publications

(1 citation statement)

References 33 publications

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“…In accordance with specific studies on this subject, we chose the clinical finding of a more than twofold distended bowel proximal to the anastomosis. This is in accordance with values found in an experimental obstruction model [37]. Nevertheless, even though a certain degree of constriction occurs at the anastomotic level, it is not clear whether it reaches a critical point at which symptoms occur [12].…”

Section: Discussionsupporting

confidence: 87%

Collagen fleeces do not improve colonic anastomotic strength but increase bowel obstructions in an experimental rat model

Schreinemacher

Bloemen

Heijden

et al. 2011

Int J Colorectal Dis

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PurposeTo investigate whether a collagen fleece kept in place by fibrin glue might seal off a colorectal anastomosis, provide reinforcement, and subsequently improve anastomotic healing.MethodsWistar rats underwent a 1-cm left-sided colonic resection followed by a 4-suture end-to-end anastomosis. They were then randomly assigned to one of three treatment groups: no additional intervention (control, n = 20), the anastomosis covered with fibrin glue (fibrin glue, n = 20), the anastomosis covered with a collagen fleece, kept in place with fibrin glue (collagen fleece, n = 21). At either 3 or 7 days follow-up, anastomotic bursting pressure was measured and tissue was obtained for histology and collagen content assessment after which animals were sacrificed.ResultsThree rats in the control (15%), three in the fibrin glue (15%), and one in the collagen group (4.8%) died due to anastomotic complications (P = 0.497). Anastomotic bursting pressures were not significantly different between groups at 3 and 7 days follow-up (P = 0.659 and P = 0.427, respectively). However, bowel obstructions occurred significantly more often in the collagen group compared to the control group (14/21 vs. 3/20, P = 0.003). Collagen contents were not different between groups, but histology showed a more severe inflammation in the collagen group compared to the other groups at both 3 and 7 days follow-up.ConclusionsA collagen fleece kept in place by fibrin glue does not improve healing of colonic anastomoses in rats. Moreover, this technique induces significantly more bowel obstructions in rats, warranting further study before being translated to a clinical setting.

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Section: Discussionsupporting

confidence: 87%