volume 24, issue s2, P5-16 2011
DOI: 10.3233/jad-2011-101941
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Georges Rammouz, Laurent Lecanu, Paul Aisen, Vassilios Papadopoulos

Abstract: Alzheimer's disease (AD) is a progressive, yet irreversible, neurodegenerative disease for which there are limited means for its ante-mortem diagnosis. We previously identified a brain- and cell-specific oxidative stress-mediated mechanism for dehydroepiandrosterone (DHEA) biosynthesis present in rat, bovine, and human brain, independent of the cytochrome P450 17α-hydroxylase/17,20-lyase (CYP17) enzyme activity found in the periphery. This alternative pathway is induced by pro-oxidant agents, such as Fe2+ and …

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