A large cohort study of the effects of Lewis, <scp>ABO</scp>, 13 other blood groups, and secretor status on <scp>COVID</scp>‐19 susceptibility, severity, and long <scp>COVID</scp>‐19

Moslemi, Camous; Sækmose, Susanne Gjørup; Larsen, Rune; Brodersen, Thorsten; Didriksen, Maria; Hjalgrim, Henrik; Banasik, Karina; Nielsen, Kaspar René; Bruun, Mie Topholm; Dowsett, Joseph; Kasperen, Kathrine A.; Mikkelsen, Susan; Hansen, Thomas; Ullum, Henrik; Erikstrup, Christian; Olsson, Martin L.; Ostrowski, Sisse Rye; Pedersen, Ole Birger

doi:10.1111/trf.17170

Cited by 19 publications

(16 citation statements)

References 42 publications

(146 reference statements)

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“…The selective force is presumed to be several pathogens. In fact, non-secretors have been reported to be highly resistant to noroviruses and rotaviruses, and more recently, to COVID-19 infection, albeit weakly [30][31][32]. In addition, recent studies have suggested that secretor status affects susceptibility to a variety of clinical conditions, including some infectious diseases, inflammatory bowel disease, and plasma vitamin B12 levels [33][34][35][36][37][38][39][40].…”

Section: Discussionmentioning

confidence: 99%

Detection of c.375A>G, c.385A>T, c.571C>T, and Sedel2 of FUT2 by Real-time PCR in a Single Tube

Soejima¹,

Koda²

2023

Preprint

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The α(1,2)fucosyltransferase (Se enzyme) encoded by FUT2 is involved in the secretor status of ABH(O) blood group antigens. The sedel2 allele is one of the non-functional FUT2 (se) alleles in which 9.3 kb containing the entire coding region of FUT2 is deleted by Alu-mediated nonhomologous recombination. In addition to this allele, three SNPs of FUT2, c.375A>G, c.385A>T, and c.571C>T, appear to be prevalent in certain Oceanian populations such as Polynesians. Recently, we developed an endpoint genotyping assay to determine the sedel2 zygosity, using a FAM-labeled probe for detection of the sedel2 allele and a VIC-labeled probe for detection of FUT2. In this study, instead of the VIC probe, a HEX-labeled probe covering both c.375A>G and c.385A>T and a Cy5-labeled probe covering c.571C>T were added to the sedel2 allele assay mixture to allow simultaneous detection of these four variations by endpoint genotyping for the sedel2 zygosity and fluorescence melting curve analysis for c.375A>G, c.385A>T, and c.571C>T genotyping. The results obtained from 24 Samoan subjects with this method were identical to those obtained with previous methods. Therefore, it appears that present method can accurately determine these four variations simultaneously.

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Section: Discussionmentioning

confidence: 99%

Detection of c.375A>G, c.385A>T, c.571C>T, and Sedel2 of FUT2 by Real-time PCR in a Single Tube

Soejima¹,

Koda²

2023

Preprint

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“…A study on the relationship between ABO blood groups and Long COVID infection severity shows that patients with AB blood group have persistent symptoms [ 14 ]. A large cohort study in Denmark, published in 2023, tried to explore the correlation between Long COVID and blood groups but no association was found [ 15 ]. To the best of our knowledge, no research has been carried out on this topic at both local and national levels in Pakistan.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Long COVID Syndrome and its Association With Blood Group: A Cross-Sectional Study

Butt,

Abdullah,

Waseem

et al. 2024

Cureus

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Background: The coronavirus disease 2019 (COVID-19) virus pandemic rapidly spread across the globe since 2020. It was characterized by a number of acute signs and symptoms. There were, however, some new-onset signs and symptoms labelled as “Long COVID”. This study was conducted to study its prevalence and associations with blood group. Methods: A retrospective analysis was conducted in Islamabad for patients diagnosed with COVID-19 in 2020-2021. Information was collected through an online and physical questionnaire regarding personal demographics, symptoms during and after COVID-19, and blood group. The data was analyzed using IBM SPSS Statistics for Windows, Version 25.0 (Released 2017; IBM Corp., Armonk, New York, United States). Results:The study identified 196 participants out of which 48.5% were male and 51% were female, with a median age of 30. Most participants (62.2%) belonged to the Punjabi ethnicity. The mean BMI was 25.56 kg/m 2 . The majority of the study participants reported having blood group B (n=76) followed by A (n=52). Acute symptoms were experienced by 95.4% of participants, with fatigue being the most persistent symptom at four weeks (45.9%). After four weeks, 63.3% of participants reported new symptoms like hair loss. Females were found more likely to experience long COVID symptoms. The perceived severity of acute infection was significantly associated with long COVID symptoms (p=<0.01). There was no association found between long COVID and blood group (p=0.158). Conclusion: There was no association found between long COVID and ABO blood groups. Females were more likely than males to experience long COVID. Long COVID was found to be more likely to develop in those with perceived severe acute infection, highlighting the need for further research regarding aggressive care from the onset of COVID-19 infection.

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“…2 The relationship between COVID-19 contraction and blood group types was still being debated. Although many have used big sample sizes to illustrate the presence of a clear link, 3–6 several other investigations have shown no connection between COVID-19 infection and blood types. 7–10 The ABO locus has been linked to genetic connections with both infection risk and disease severity.…”

Section: Introductionmentioning

confidence: 99%

Association of ABO blood types and clinical variables with COVID-19 infection severity in Libya

Abdulla,

Elawamy,

Mohamed

et al. 2023

SAGE Open Medicine

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Objective: The continuing COVID-19 pandemic is a coronavirus-related health emergency (severe acute respiratory syndrome coronavirus 2). Inadequate efforts are still being made to address the illness situation in Libya, and this must change. To address these issues, we looked into the demography and trend of the disease as well as the potential risk factors for infection. Methods: This study is a retrospective case–control study conducted online among 616 COVID-19 patients. The p0.05 value, odds ratios, and 95% confidence intervals were calculated and analyzed from the drawn data. Results: Males were at high risk of COVID-19 than females (odds ratio = 1.3, 95% confidence interval: 1.042–1.622; p = 0.02). Anosmia and ageusia were more prominent in females. Patients with an “AB” blood group are significantly susceptible to infection. Adults (31 and above) are highly liable to infection. The univariate logistic regression analysis revealed that smoking is a risk factor for those above 60 years (odds ratio = 2.228, 95% confidence interval: 1.145–4.336; p = 0.018). Individuals with chronic diseases such as diabetes and/or hypertension are more prone to COVID-19 (odds ratio = 10.045, 95% confidence interval: 3.078–32.794; p = 0.000 and odds ratio = 11.508, 95% confidence interval: 3.930–33.695; p = 0.000, respectively). Conclusion: This study provided for the first time the demographic data and the trend of COVID-19 infection in Libya, which will assist the stakeholders and governmental bodies in planning protection strategies against the pandemic.

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A large cohort study of the effects of Lewis, ABO, 13 other blood groups, and secretor status on COVID‐19 susceptibility, severity, and long COVID‐19

Cited by 19 publications

References 42 publications

Detection of c.375A>G, c.385A>T, c.571C>T, and Sedel2 of FUT2 by Real-time PCR in a Single Tube

Detection of c.375A>G, c.385A>T, c.571C>T, and Sedel2 of FUT2 by Real-time PCR in a Single Tube

Prevalence of Long COVID Syndrome and its Association With Blood Group: A Cross-Sectional Study

Association of ABO blood types and clinical variables with COVID-19 infection severity in Libya

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