2012
DOI: 10.1089/ten.tea.2011.0279
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Abstract: Osteoarthritis is the leading cause of physical disability among Americans, and tissue engineered cartilage grafts have emerged as a promising treatment option for this debilitating condition. Currently, the formation of a stable interface between the cartilage graft and subchondral bone remains a significant challenge. This study evaluates the potential of a hybrid scaffold of hydroxyapatite (HA) and alginate hydrogel for the regeneration of the osteochondral interface. Specifically, the effects of HA on the … Show more

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Cited by 108 publications
(101 citation statements)
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“…Tissue engineering applications aim to replace or regenerate damaged tissues through the combinations of cells, three-dimensional scaffolds and signalling molecules [4][5]. A number of strategies have been implemented to engineer osteochondral constructs including bi-phasic scaffolding [6][7][8][9][10][11][12], bioreactor technologies [13][14][15][16], and growth factor/gene delivery [17][18][19][20]. Engineered anatomically accurate osteochondral grafts have also been suggested as a potential approach to joint condyle repair [21][22].…”
Section: Introductionmentioning
confidence: 99%
“…Tissue engineering applications aim to replace or regenerate damaged tissues through the combinations of cells, three-dimensional scaffolds and signalling molecules [4][5]. A number of strategies have been implemented to engineer osteochondral constructs including bi-phasic scaffolding [6][7][8][9][10][11][12], bioreactor technologies [13][14][15][16], and growth factor/gene delivery [17][18][19][20]. Engineered anatomically accurate osteochondral grafts have also been suggested as a potential approach to joint condyle repair [21][22].…”
Section: Introductionmentioning
confidence: 99%
“…The combination of biodegradable polymers and bioactive ceramics in a variety of composite structures is promising in this area, whereby the fabrication methods, associated cells and signaling factors determine the success of the strategies 39 . In this regard, the use of hydrogels can enhance osteochondral repair 40,41 . Recently, Hannink et al 42 evaluated if a porous polycaprolactone-polyurethane scaffold, currently used for partial meniscal replacement in clinical practice, could initiate regeneration and repair of osteochondral defects, and if regeneration and repair were related to mechanical stimulation in New Zealand White rabbits.…”
Section: Resultsmentioning
confidence: 99%
“…46,47 This goal still holds today, and we have seen major progress in the ability to shape grafts to mirror patient anatomy 48,49 and incorporate an osteochondral interface. 50,51 Miniaturization of bone tissue engineering is now leading to in vitro models for studying primary and metastatic bone cancer, [52][53][54] and for better recapitulating the physiological and pathophysiological states of bone marrow hematopoiesis.…”
Section: Bone Microplatformsmentioning
confidence: 99%