A human model for assessing comedogenic substances

Mills, O. H.

doi:10.1001/archderm.118.11.903

Cited by 28 publications

(24 citation statements)

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“…Fulton [36] described the comedogenicity of an extensive list of commonly used ingredients in skincare products of which mineral oil was reported to be mildly comedogenic but nowhere near as much as other ingredients. Conflicting results were found by Mills and Kligman [37] in their rabbit and human models, in which mineral oil was reported not to be comedogenic. The American Academy of Dermatology proposed guidelines to try to interpret the differences in the animal to human data, and they concluded that 1-2 comedones in animal testing would be unlikely to be an indicator of comedogenicity in humans [38].…”

Section: ó 2012 Society Of Cosmetic Scientists and The Société Françamentioning

confidence: 83%

A review on the extensive skin benefits of mineral oil

Rawlings¹,

Lombard

2012

Intern J of Cosmetic Sci

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Synopsis This review was initially prepared in 2011 before Professor Johann Wiechers tragically passed away. It has been updated and is being published in his memory. It discusses the importance of mineral oil and its benefits to skin. Its source, structure, properties and efficacy are discussed. Mineral oil has been shown to improve skin softness and barrier function better than some other emollients using the gas‐bearing dynamometer and standard water vapour transmission testing as well as in vivo studies showing its effects on suppressing transepidermal water loss (TEWL). It has also been subjected to the rigour of the newer in vivo confocal microscopic measurements now used for testing the performance of moisturizers by following the swelling characteristics of the stratum corneum and been found favourable compared with many vegetable oils. Its introduction as a cosmetic oil was in the late 1800s, and still today, it is used as one of the main components of moisturizers, a true testament to its cost to efficacy window. Naturally, it has physical effects on the stratum corneum, but it is expected that these will translate into biological effects simply through its mechanism of hydrating and occluding the stratum corneum from which many benefits are derived.

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Section: ó 2012 Society Of Cosmetic Scientists and The Société Françamentioning

confidence: 83%

A review on the extensive skin benefits of mineral oil

Rawlings¹,

Lombard

2012

Intern J of Cosmetic Sci

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“…This particular form of acne was called ‘acne cosmetica’ and was clinically characterized by multiple comedones, in contrast to the present cases [1]. In addition, nowadays, cosmetic companies are carefully testing their compounds for comedogenicity before marketing, and cosmetics are an infrequent cause of acne [4,5,6]. Our first patient applied a skin repair cream containing copper-zinc, resveratrol and hyaluronic acid.…”

Section: Discussionmentioning

confidence: 99%

Exogenous Inflammatory Acne due to Combined Application of Cosmetic and Facial Rubbing

Sénéschal

Kubica²,

Boursault³

et al. 2012

Dermatology

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Background: Exogenous acne refers to acneiform lesions due to external factors such as cosmetic agents, exposure to various oils, skin rubbing or friction or chloracne, now better called metabolizing acquired dioxin-induced skin hamartoma (MADISH). Here we report a new form of severe inflammatory exogenous acne due to the association of two factors: facial friction with cosmetic agents. Observations: A 15-, 17- and 19-year-old female presented at the department with severe inflammatory acne. In all cases, the face had been strongly rubbed in a compulsory manner in the previous weeks with cosmetic agents. The disease has not responded to various conventional acne treatments and was well controlled by a combination of oral corticosteroids and low-dose isotretinoin. Conclusion: Because cosmetic face friction as a cosmetic care becomes more and more fashionable, dermatologists should be aware of this severe clinical condition, which can occur in patients without a personal history of acne.

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“…CFB is the most reliable tool to sample the follicular content of facial skin [22,23,24]. We believe that CFB can provide a visual evaluation of acne lesions in order to obtain a more objective measurement of patients’ clinical improvement.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Aminolevulinic Acid Photodynamic Therapy on Microcomedones and Macrocomedones

et al. 2009

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Background: Photodynamic therapy (PDT) with aminolevulinic acid (ALA) has been shown to be an effective treatment for acne. However, the effect of ALA PDT on comedo formation has never been objectively evaluated. Cyanoacrylate follicular biopsy (CFB), a noninvasive procedure, has been proposed as the most reliable tool for studying follicular casts. Objective: To determine the possible effect of ALA and red light (550–700 nm) on macro- and microcomedones in acne patients. Patients and Methods: 10 patients with mild-to-moderate facial and/or chest/back acne resistant to conventional therapies received ALA PDT at 2-week intervals in 3 sessions. The severity of acne had been estimated by a system of points, the Global Acne Grading System. The patients underwent PDT utilizing ALA 10% (face) or 15% (back/chest) and red light (15 J/cm² each session). CFBs were performed. Results: Four weeks after their last PDT session, the patients showed an average global score reduction of 50%. CFBs demonstrated a reduction in the total area, the average area and the density of macrocomedones. Conclusion: The results obtained in this study using CFB evaluation demonstrate that ALA PDT exerts an action on the comedogenic phase as well.

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A human model for assessing comedogenic substances

Cited by 28 publications

References 0 publications

A review on the extensive skin benefits of mineral oil

A review on the extensive skin benefits of mineral oil

Exogenous Inflammatory Acne due to Combined Application of Cosmetic and Facial Rubbing

The Effect of Aminolevulinic Acid Photodynamic Therapy on Microcomedones and Macrocomedones

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