A histopathological variant of mixed thymoma presenting with prominent calcification and desmoplasia in an aged Japanese Brown cow

Ohfuji, S.

doi:10.1007/s00580-013-1833-2

Cited by 1 publication

(1 citation statement)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Amur tiger; Panthera tigris altaica). [2][3][4][5][6][7][8]10,11,13,[16][17][18][19][20][21][22][23][24]27 In animals, thymomas are classified as lymphoid, epithelial, and mixed types on the basis of the predominant cell population of the neoplasm. 9 The epithelial thymoma can be further classified as clear-cell and spindle-cell subtypes based on the histologic features of the neoplastic cells.…”

Section: Research-article2016mentioning

confidence: 99%

Concurrent spindle-cell thymoma and thymic cysts in a Barbary sheep (Ammotragus lervia)

Chang

Jeng

et al. 2016

J VET Diagn Invest

View full text Add to dashboard Cite

An ~21-year-old female Barbary sheep (Ammotragus lervia) died spontaneously following a lengthy episode of difficulty in walking. An ~6 × 3 × 3 cm, unilocular cystic growth was found in the cranioventral thorax. The fibrotic cystic wall, lined by a single layer of flattened to cuboidal epithelial cells, was invaginated and partially encircled solid masses of fusiform neoplastic cells with multiple intratumoral cystic structures. The fusiform neoplastic cells were intensely positive for cytokeratin (CK) and partially positive for α-smooth muscle actin and vimentin, but negative for thyroid transcription factor-1 (TTF-1) and neuron-specific enolase (NSE). The intratumoral cysts were lined by CK-positive but TTF-1- negative, NSE-negative, flattened, cuboidal to columnar epithelial cells, suggestive of cystically dilated medullary duct epithelium-derived structures. Based on the location and histopathologic findings of the growth, concurrent spindle-cell thymoma and thymic cysts was diagnosed. We also discuss the correlation between thymic cysts and thymoma and review the literature of thymomas in ovine and wildlife species.

show abstract