A highly sensitive UHPLC-MS/MS method for urine biological monitoring of occupational exposure to anthracycline antineoplastic drugs and routine application

Villa, Antoine; Tremolet, Kévin; Martínez, Béatrice; Cacao, Oscar Da Silva; Atgé, Benoît; Ducint, Dominique; Titier-Debeaupuis, Karine; Verdun-Esquer, Catherine; Molimard, Mathiéu; Canal-Raffin, Mireille

doi:10.1016/j.jchromb.2020.122305

Cited by 10 publications

(4 citation statements)

References 22 publications

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“…Doxorubicin and EPI are prescribed in the treatment of various cancers, including breast, digestive, hematological, bronchopulmonary, and ovarian cancers. Daunorubicin is used in the treatment of hematological cancers [ 33 ]. Villa et al [ 33 ] monitored more than 77 workers for anthracycline AD exposure.…”

Section: Resultsmentioning

confidence: 99%

“…Daunorubicin is used in the treatment of hematological cancers [ 33 ]. Villa et al [ 33 ] monitored more than 77 workers for anthracycline AD exposure. Two healthcare professionals were found to be contaminated by anthracycline drugs which represents the 2.6% of the monitored population.…”

Section: Resultsmentioning

confidence: 99%

“…Additionally, exposure by inhalation, in fact, may result in a very quick uptake and excretion in the urine, while exposure via the skin can cause a postponed excretion over a longer period, maybe in relation to the barrier function of the skin. Currently, a suitable risk assessment for healthcare professionals occupationally exposed to ADs is prevented by the lack of biological limit values (BLVs) or biological guidance values (BGVs) [ 33 ]. Moreover, the health impact of low-dose internal contamination level of ADs is not currently known and the concentrations retrieved in biological matrices cannot be easily interpreted.…”

Section: Discussionmentioning

confidence: 99%

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Exposure to Antineoplastic Drugs in Occupational Settings: A Systematic Review of Biological Monitoring Data

Leso

Sottani

Santocono

et al. 2022

IJERPH

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The high toxicity of antineoplastic drugs (ADs) makes them dangerous not only for patients, but also for exposed workers. Therefore, the aim of this review was to provide an updated overview of the biological monitoring of occupational AD exposure in order to extrapolate information useful to improve risk assessment and management strategies in workplaces. Several studies demonstrated that remarkable portions of healthcare workers may have traces of these substances or their metabolites in biological fluids, although with some conflicting results. Nurses, directly engaged in AD handling, werethe occupational category at higher risk of contamination, although, in some cases, personnel not involved in AD-related tasks also showed quantifiable internal doses. Overall, further research carried out on greater sample sizes appears necessary to gain deeper insight into the variability retrieved in the reported results. This may be important to understand the impact of the extent of ADs use, different handling, procedures, and cleaning practices, spill occurrence, training of the workforce, as well as the adoption of adequate collective and personal protective equipment in affecting the occupational exposure levels. This may support the achievement of the greatest clinical efficiency of such therapies while assuring the health and safety of involved workers.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Exposure to Antineoplastic Drugs in Occupational Settings: A Systematic Review of Biological Monitoring Data

Leso

Sottani

Santocono

et al. 2022

IJERPH

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“…The data reported in the literature involves two to eleven medical centers, and the proportions of contaminated professionals were highly variable. A low percentage of contaminated workers, less than 20%, were reported in Europe [ 16 , 17 , 18 , 19 , 20 , 21 ]. Some other studies reported higher proportions of contaminated HCWs, >50% [ 22 , 23 , 24 ].…”

Section: Discussionmentioning

confidence: 99%

Occupational Exposure to Antineoplastic Drugs in Twelve French Health Care Setting: Biological Monitoring and Surface Contamination

Ndaw

Rémy

2023

IJERPH

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Antineoplastic drugs used in the treatment of cancers have an intrinsic toxicity, because of their genotoxic, teratogenic, and carcinogenic properties. Their use is recognized as an occupational hazard for healthcare workers (HCWs) who may be exposed. The purpose of this article is to present biological- and environmental-monitoring data collected in twelve French hospitals over eight years. Urine samples were collected from a wide range of HCWs (250 participants) from pharmacy and oncology units, including physicians, pharmacists, pharmacy technicians, nurses, auxiliary nurses, and cleaners. The investigated drugs were cyclophosphamide, ifosfamide, methotrexate, and α-fluoro-β-alanine, the main urinary metabolite of 5-fluorouracil. Wipe samples were collected from various locations in pharmacy and oncology units. More than 50% of participants, from all exposure groups, were contaminated with either drug, depending on the unit, the day, or the task performed. However, workers from oncology units were more frequently exposed than workers from pharmacy units. Significant contamination was detected on various surfaces in pharmacy and oncology units, highlighting potential sources of exposure. Risk-management measures should be implemented to reduce and maintain exposures at lowest-possible levels. In addition, regular exposure assessment, including biological and environmental monitoring, is recommended to ensure the long-term efficiency of the prevention measures.

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Nurses’ internal contamination by antineoplastic drugs in hospital centers: a cross-sectional descriptive study

Villa

Molimard

Sakr

et al. 2021

Int Arch Occup Environ Health

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A highly sensitive UHPLC-MS/MS method for urine biological monitoring of occupational exposure to anthracycline antineoplastic drugs and routine application

Cited by 10 publications

References 22 publications

Exposure to Antineoplastic Drugs in Occupational Settings: A Systematic Review of Biological Monitoring Data

Exposure to Antineoplastic Drugs in Occupational Settings: A Systematic Review of Biological Monitoring Data

Occupational Exposure to Antineoplastic Drugs in Twelve French Health Care Setting: Biological Monitoring and Surface Contamination

Nurses’ internal contamination by antineoplastic drugs in hospital centers: a cross-sectional descriptive study

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