A highly sensitive label-free amperometric biosensor for norfloxacin detection based on chitosan-yttria nanocomposite

Yadav, Amit K.; Dhiman, Tarun Kumar; Lakshmi, G.B.V.S.; Berlina, Anna N.; Solanki, Pratima R.

doi:10.1016/j.ijbiomac.2020.02.089

Cited by 64 publications

(29 citation statements)

References 60 publications

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“…The developed biosensor was used to detect trace amounts of the antibiotic norfloxacin. The diagnostic characteristics of the fabricated sensor when measured using differential pulse voltammetry proved to be better compared to previously described biosensors and commercially available EIA in terms of sensitivity and a lower detection limit [118].…”

Section: The Use Of Physico-chemical Methods For the Development Of Immunosensorsmentioning

confidence: 80%

Antibodies as Biosensors’ Key Components: State-of-the-Art in Russia 2020–2021

Rudenko

Fursova

Shepelyakovskaya

et al. 2021

Sensors

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The recognition of biomolecules is crucial in key areas such as the timely diagnosis of somatic and infectious diseases, food quality control, and environmental monitoring. This determines the need to develop highly sensitive display devices based on the achievements of modern science and technology, characterized by high selectivity, high speed, low cost, availability, and small size. Such requirements are met by biosensor systems—devices for reagent-free analysis of compounds that consist of a biologically sensitive element (receptor), a transducer, and a working solution. The diversity of biological material and methods for its immobilization on the surface or in the volume of the transducer and the use of nanotechnologies have led to the appearance of an avalanche-like number of different biosensors, which, depending on the type of biologically sensitive element, can be divided into three groups: enzyme, affinity, and cellular/tissue. Affinity biosensors are one of the rapidly developing areas in immunoassay, where the key point is to register the formation of an antigen–antibody complex. This review analyzes the latest work by Russian researchers concerning the production of molecules used in various immunoassay formats as well as new fundamental scientific data obtained as a result of their use.

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Section: The Use Of Physico-chemical Methods For the Development Of Immunosensorsmentioning

confidence: 80%

Antibodies as Biosensors’ Key Components: State-of-the-Art in Russia 2020–2021

Rudenko

Fursova

Shepelyakovskaya

et al. 2021

Sensors

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show abstract

“…177 In this method, the electron movement on account of biochemical reactions, and the immobilization of biological analytes, both occur on the electrodes. [178][179][180] Based on operating principles, electrochemical biosensors are divided into four types-potentiometric, amperometric, conductimetric, and impedimetric. 181,182 The first diagnostic biosensor was established in 1967 for blood glucose levels detection employing natural human enzyme (glucose oxidase) using an electrochemical detector.…”

Section: Interleukins: Biomarkers Of Clinical Usesmentioning

confidence: 99%

Review—Interleukins Profiling for Biosensing Applications: Possibilities and the Future of Disease Detection

et al. 2022

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Interleukins (ILs) are a major subclass of cytokines which act as molecular messengers playing a role in immune system responses via cascade of signalling pathways. Belonging to the cytokine family, ILs play a crucial role in the theronostics of various diseases. Their abnormal expression leads to development of various diseases such as cancer, neurodegenerative diseases, allergies, asthma, autoimmune diseases, and other physiological abnormalities. This paves the way for exploring ILs to develop sensitive and efficient biosensors, and promoting them for clinical testing in a wide array of diseases. Furthermore, detecting the level of ILs is very important for their early diagnosis and their progression within the body, and simultaneously for possible immunotherapeutic approaches. To achieve this goal, multidisciplinary scientific approaches involving immunology, electrochemistry, nanotechnology, photometry, etc. are already being put into action. Advancements in nanoscience and nanotechnology are aiding in the development of highly sensitive biosensors for ILs detection. This review focuses on a detailed description of all presently discovered ILs and their roles in various diseases. Simultaneously, it also discusses the various electrochemical biosensors that can be employed for the detection of ILs in bodily fluids. Moreover, the role of nanomaterials in electrochemical biosensing are also discussed here.

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“…The calculated D value for the MIP/ITO electrode was found to be higher, i.e., 2.97 × 10 −11 cm 2 s −1 , in comparison to that for the NIP/ITO electrode, i.e., 2.16 × 10 −11 cm 2 s −1 showing a high electron transfer rate at the electrode surface/electrolyte. Moreover, the Brown-Anson formula was utilized for calculating the surface concentration of the absorbed ionic electroactive species (I*) as depicted in eqn (9); 52 Ae ¼…”

Section: Scan Rate Studymentioning

confidence: 99%