2002
DOI: 10.1093/chemse/27.5.461
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Abstract: Little is known about how specific genes influence taste function in mammals. One of the most promising ways to fill this void is to screen the progeny of chemically mutagenized (or genetically altered) mice for aberrant taste phenotypes and then identify the mutated gene(s) that is associated with each taste anomaly. To exploit this approach, a high-throughput and robust screening procedure is needed. We have attempted to meet this demand by developing an automated procedure that assesses taste responsiveness… Show more

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Cited by 167 publications
(171 citation statements)
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References 42 publications
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“…The results from the gustometer test and the taste-reactivity paradigm are similar to those reported previously in mice, both in terms of the magnitude and level of increase in the standardized lick ratio with increasing sucrose concentration in the gustometer test (see, eg, Glendinning et al, 2002) and also in the number of positive hedonic reactions displayed with increasing sucrose concentration during the 5-min taste-reactivity test sessions (Cagniard and Murphy, 2009;Pecina et al, 2003). Together, these results indicate that hedonic reaction to appetitive stimuli is not compromised in D2R-OE mice.…”
Section: D2r Overexpression Does Not Impact Consummatory Behavior or supporting
confidence: 86%
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“…The results from the gustometer test and the taste-reactivity paradigm are similar to those reported previously in mice, both in terms of the magnitude and level of increase in the standardized lick ratio with increasing sucrose concentration in the gustometer test (see, eg, Glendinning et al, 2002) and also in the number of positive hedonic reactions displayed with increasing sucrose concentration during the 5-min taste-reactivity test sessions (Cagniard and Murphy, 2009;Pecina et al, 2003). Together, these results indicate that hedonic reaction to appetitive stimuli is not compromised in D2R-OE mice.…”
Section: D2r Overexpression Does Not Impact Consummatory Behavior or supporting
confidence: 86%
“…In previous studies, both mice and rats show increased licking as sucrose concentration increases, and this is thought to reflect the palatability of the sucrose solution (Glendinning et al, 2002;Spector et al, 1993). Figure 1 shows that under the lowest concentration of sucrose, lick ratios obtained from both control and D2R-OE mice were around 0.20, indicating that the mice were licking at a rate of around 20% of their baseline licking rate.…”
Section: D2r Overexpression Does Not Alter Reactivity To Sucrosementioning
confidence: 73%
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“…Each stimulus and concentration was presented in three independent test sessions in 5-s trials. Intertrial intervals were 7.5 s during a 20-min session as reported previously (68,(95)(96)(97)(98). For detailed information about substances see Table 3 and supplemental Table 1S.…”
Section: Methodsmentioning
confidence: 99%
“…Electric sensors are most commonly used, and typically depend on a high-frequency ac contact circuit. Commercially available lickometers designed for use with rats and mice come at a cost of a few hundred to several thousand dollars, and vary widely in application, from those used to monitor licks from a single spout/bottle to those capable of switching between multiple spouts/bottles (Glendinning et al, 2002;Hill and Stellar, 1951;Smith, 2001). Here we describe a method that allows the reliable and temporally precise measurement of the licking behavior at virtually no cost, provided that a standard analog-to-digital converter is available.…”
Section: Introductionmentioning
confidence: 99%