Berenice Franco-Juárez, Fanny Mejía-Martínez, Elizabeth Moreno-Arriola, Alain Hernández-Vázquez, Saul Gómez-Manzo, Jaime Marcial-Quino, Roberto Arreguín-Espinosa, Antonio Velázquez-Arellano, Daniel Ortega-Cuellar
Abstract:A high-glucose diet (HGD) is associated with the development of metabolic diseases that decrease life expectancy, including obesity and type-2 diabetes (T2D); however, the mechanism through which a HGD does so is still unclear. Autophagy, an evolutionarily conserved mechanism, has been shown to promote both cell and organismal survival. The goal of this study was to determine whether exposure of Caenorhabditis elegans to a HGD affects autophagy and thus contributes to the observed lifespan reduction under a HG…
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