2005
DOI: 10.1007/s00011-005-1380-7
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A heretofore undisclosed crux of Eosinophilia-Myalgia Syndrome: compromised histamine degradation

Abstract: In contrast to early epidemiological evidence offering links between eosinophilia-myalgia syndrome (EMS) and microimpurities of L-tryptophan-containing dietary supplements (LTCDS), this account shows why reliance on a finite impurity from one manufacturer is both unnecessary and insufficient to explain the etiology of EMS. Excessive histamine activity has induced blood eosinophilia and myalgia (Greek: mys, muscle + algos, pain). Termination of the multiple actions of histamine is dependent on particular amine … Show more

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Cited by 29 publications
(17 citation statements)
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“…Our study highlights a new and previously unappreciated role of MCs through AhR activation in orchestrating inflammatory responses. This could be extended to all those pathologies where tissue/organ homeostasis is broken by an inflammatory MC-rich infiltrate, likely accessible by AhR ligands derived from tryptophan metabolism, such as inflammatory bowel disease (3) and eosinophilia-myalgia syndrome (46).…”
Section: Discussionmentioning
confidence: 99%
“…Our study highlights a new and previously unappreciated role of MCs through AhR activation in orchestrating inflammatory responses. This could be extended to all those pathologies where tissue/organ homeostasis is broken by an inflammatory MC-rich infiltrate, likely accessible by AhR ligands derived from tryptophan metabolism, such as inflammatory bowel disease (3) and eosinophilia-myalgia syndrome (46).…”
Section: Discussionmentioning
confidence: 99%
“…Other reports indicated that this subset approached 4-5 %. Moreover, (non-EMS) subjects with hypothalamic-pituitary-adrenal axis dysregulation have manifested increased sensitivities to incurred tryptophan and histamine [1].…”
Section: Resultsmentioning
confidence: 99%
“…Though relatively rare in Western societies, hypereosinophilic heart disease -including endomyocardial fi brosis with eosinophilia -has been estimated to cause 10-20 % of all cardiac mortalities in Southeast Asia and tropical Africa, where it remains endemic [7]. According to Fernex, "in histological material a higher concentration of mast cells was regularly observed in Africans in the interstitium of the myocardium and in the skin" (see [1] for reference). According to Spry, "eosinophils have an important relationship with a number of heart diseases.…”
Section: Resultsmentioning
confidence: 99%
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