A heparin-modified palladium nanozyme for photometric determination of protamine

Huang, Qinghong; Zhang, Jinli; Li, Wei; Fu, Yan

doi:10.1007/s00604-020-4208-9

Cited by 13 publications

(6 citation statements)

References 33 publications

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“…Furthermore, the nanomaterials that contain other transition metals including V [46,47], Zn [48], Co [49], Mn [50], Mo [51], W [52], Cu [53], Au [54], Ag [55], Pt [56], Pd [57], Ir [58], Os [59], and Ru [60] can also behave as PODs. André et al found that V 2 O 5 nanowires with intrinsic POD-like activity could catalyze the oxidation of the POD substrates including 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and TMB with the help of H 2 O 2 [46].…”

Section: Pod-like Nanozymesmentioning

confidence: 99%

Nanozymes: Versatile Platforms for Cancer Diagnosis and Therapy

2022

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Natural enzymes usually suffer from high production cost, ease of denaturation and inactivation, and low yield, making them difficult to be broadly applicable. As an emerging type of artificial enzyme, nanozymes that combine the characteristics of nanomaterials and enzymes are promising alternatives. On the one hand, nanozymes have high enzyme-like catalytic activities to regulate biochemical reactions. On the other hand, nanozymes also inherit the properties of nanomaterials, which can ameliorate the shortcomings of natural enzymes and serve as versatile platforms for diverse applications. In this review, various nanozymes that mimic the catalytic activity of different enzymes are introduced. The achievements of nanozymes in different cancer diagnosis and treatment technologies are summarized by highlighting the advantages of nanozymes in these applications. Finally, future research directions in this rapidly developing field are outlooked."Image missing"

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Section: Pod-like Nanozymesmentioning

confidence: 99%

Nanozymes: Versatile Platforms for Cancer Diagnosis and Therapy

2022

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“…Similar to these nanoparticles, other nanomaterials containing iron can also be used as POD mimetics. In addition, nanomaterials containing other transition metals, including Au ( 41 ), Ag ( 42 ), Pt ( 43 ), Pd ( 44 ), Ir ( 45 ), and Ru ( 46 ), can also serve as PODs ( 47 ).…”

Section: Noble Metal Biomimetic Nanozymesmentioning

confidence: 99%

Latest advances in biomimetic nanomaterials for diagnosis and treatment of cardiovascular disease

Gong

Liu

Shi

et al. 2023

Front. Cardiovasc. Med.

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Cardiovascular disease remains one of the leading causes of death in China, with increasingly serious negative effects on people and society. Despite significant advances in preventing and treating cardiovascular diseases, such as atrial fibrillation/flutter and heart failure over the last few years, much more remains to be done. Therefore, developing innovative methods for identifying and managing cardiovascular disorders is critical. Nanomaterials provide multiple benefits in biomedicine, primarily better catalytic activity, drug loading, targeting, and imaging. Biomimetic materials and nanoparticles are specially combined to synthesize biomimetic nanoparticles that successfully reduce the nanoparticles’ toxicity and immunogenicity while enhancing histocompatibility. Additionally, the biological targeting capability of nanoparticles facilitates the diagnosis and therapy of cardiovascular disease. Nowadays, nanomedicine still faces numerous challenges, which necessitates creating nanoparticles that are highly selective, toxic-free, and better clinically applicable. This study reviews the scientific accomplishments in this field over the past few years covering the classification, applications, and prospects of noble metal biomimetic nanozymes and biomimetic nanocarriers.

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“…[1,2] Found mainly in the nucleus of mature fish sperm, protamine is widely used in heart surgery, anti-tumor, food preservative and antigenic carriers. [3][4][5][6] Protamine has significant pharmacological effects and appropriate doses of protamine function as a hem agglutinant, antivenin agent, heparin antagonist and insulin sustained-release agent. [7][8][9] At a concentration in plasma of 0.05 mg (5 units/mL), heparin renders the plasma incoagulable, while protamine produces only a mild-to-moderate lengthening of activated partial thromboplastin time (APTT) and prothrombin time (PT).…”

Section: Introductionmentioning

confidence: 99%

Modifying Fluorescent Protein Chromophore to Detect Protamine and Application in Real Serum Samples

Gao,

Li,

Xiao

et al. 2024

ChemistrySelect

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As effective methods to accurately and rapidly detect protamine remains a major challenge, here we present a fluorescent protein chromophore‐based probe (IDL‐FP) utilizing twisted‐intramolecular charge transfer (TICT) to detect protamine. The introduction of an electron‐donor group 4‐dimethylaminobenzaldehyde extends the emission wavelength of IDL‐FP to the red region. The deprotection of t‐butyloxy carbonyl groups can then generate an electronegative carboxyl group, which promotes the binding to protamine via electrostatic attraction. Thus, IDL‐FP is sensitive and specific towards protamine and can serve as a highly selective detector for protamine with a detection limit as low as 8.87 ng/mL. As IDL‐FP exhibited good stability in physiological pH environment, we successfully apply IDL‐FP to detect spiked‐in protamine in human serum. In summary, probe IDL‐FP is a promising tool for the quantitative determination of protamine.

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A heparin-modified palladium nanozyme for photometric determination of protamine

Cited by 13 publications

References 33 publications

Nanozymes: Versatile Platforms for Cancer Diagnosis and Therapy

Nanozymes: Versatile Platforms for Cancer Diagnosis and Therapy

Latest advances in biomimetic nanomaterials for diagnosis and treatment of cardiovascular disease

Modifying Fluorescent Protein Chromophore to Detect Protamine and Application in Real Serum Samples

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