A graphene quantum dot@Fe 3 O 4 @SiO 2 based nanoprobe for drug delivery sensing and dual-modal fluorescence and MRI imaging in cancer cells

Su, Xiaoqian; Chan, Chun-Yu; Shi, Jingyu; Tsang, Ming Kiu; Pan, Yi; Cheng, C.S. Agnes; Oudeng, Gerile; Yang, Mo

doi:10.1016/j.bios.2016.10.076

Cited by 146 publications

(63 citation statements)

References 36 publications

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“…Given the carbon-based chemistry and outstanding biocompatible properties, graphene oxide (GO) has attracted considerable interest among nanomaterials such as silver, zinc oxide, and magnesium oxide. 4 GO has been explored in a wide range of diagnostic and therapeutic fields, showing potential in areas such as engineered tissues, 5 drug delivery carriers, 6 biomedical imaging, 7 antibacterial materials, 8 Alzheimer's disease diagnosis, 9 and anticancer 10 therapies.…”

Section: Introductionmentioning

confidence: 99%

Mechanisms of oxidative stress, apoptosis, and autophagy involved in graphene oxide nanomaterial anti-osteosarcoma effect

Tang

Zhao

Yang

et al. 2018

IJN

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BackgroundGraphene and its derivative graphene oxide (GO) have been implicated in a wide range of anticancer effects.PurposeThe objective of this study was to systematically evaluate the toxicity and underlying mechanisms of GO on two osteosarcoma (OSA) cancer cell lines, MG-63 and K7M2 cells.MethodsMG-63 and K7M2 cells were treated by GO (0–50 µg/mL) for various time periods. Cell viability was tested by MTT and Live/Dead assays. A ROS Detection Kit based on DHE oxidative reaction was used for ROS detection. An Annexin V-FITC Apoptosis Kit was used for apoptosis detection. Dansylcadaverine (MDC) dyeing was applied for seeking unspecific autophagosomes. Western blot and Immunofluorescence analysis were used for related protein expression and location.ResultsK7M2 cells were more sensitive to GO compared with MG-63 cells. The mechanism was attributed to the different extent of the generation of reactive oxygen species (ROS). In K7M2 cells, ROS was easily stimulated and the apoptosis pathway was subsequently activated, accompanied by elevated expression of proapoptosis proteins (such as caspase-3) and decreased expression levels of antiapoptosis proteins (such as Bcl-2). A ROS inhibitor (N-acetylcysteine) could alleviate the cytotoxic effects of GO in K7M2 cells. However, the production of ROS in MG-63 cells was probably inhibited by the activation of an antioxidative factor, nuclear factor-E2-related factor-2, which translocated from the cytoplasm to the nucleus after GO treatment, while a nuclear factor-E2-related factor-2 inhibitor (ML385) significantly increased ROS production in MG-63 cells when combined with GO treatment. In addition, autophagy was simultaneously stimulated by characteristic autophagosome formation, autophagy flux, and increased the expression level of autophagy-related proteins (such as LC3I to LC3II conversion, ATG5, and ATG7).ConclusionThis paper proposes various underlying mechanisms of the anticancer effect of GO. The novel synthetic use of GO with an oxidizing agent is the key step for further potential applications in clinical OSA cancer therapy.

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Section: Introductionmentioning

confidence: 99%

Mechanisms of oxidative stress, apoptosis, and autophagy involved in graphene oxide nanomaterial anti-osteosarcoma effect

Tang

Zhao

Yang

et al. 2018

IJN

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“…Inorganic non-metallic nanomaterials mainly include quantum dots, iron oxide, silicon, grapheme, and so on (Khafaji et al, 2019). Quantum dots (QDs), that is, semiconductor nanocrystals, are particularly focused on fluorescence imaging because of their unique luminous properties, while iron oxide nanoparticles are chiefly lay on the study of new MRI contrast agents (Jayagopal et al, 2009;Hauser et al, 2016;Su et al, 2017;Wei H. et al, 2017). Among them, mesoporous silicon nanomaterials have Extremely slow biodegradation rate Yu F. et al, 2018 attracted more and more attention in the therapy of diseases in recent years due to its large surface area and porous structure (Wang W. et al, 2016).…”

Section: Inorganic Non-metallic Nanomaterialsmentioning

confidence: 99%

Application of the Nano-Drug Delivery System in Treatment of Cardiovascular Diseases

Deng

Zhang

Shen

et al. 2020

Front. Bioeng. Biotechnol.

182

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Cardiovascular diseases (CVDs) have become a serious threat to human life and health. Though many drugs acting via different mechanism of action are available in the market as conventional formulations for the treatment of CVDs, they are still far from satisfactory due to poor water solubility, low biological efficacy, non-targeting, and drug resistance. Nano-drug delivery systems (NDDSs) provide a new drug delivery method for the treatment of CVDs with the development of nanotechnology, demonstrating great advantages in solving the above problems. Nevertheless, there are some problems about NDDSs need to be addressed, such as cytotoxicity. In this review, the types and targeting strategies of NDDSs were summarized, and the new research progress in the diagnosis and therapy of CVDs in recent years was reviewed. Future prospective for nano-carriers in drug delivery for CVDs includes gene therapy, in order to provide more ideas for the improvement of cardiovascular drugs. In addition, its safety was also discussed in the review.

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“…QDs have been proved great potential in bioimaging and clinical diagnosis, attempts are made to explore further applications of QDs for cancer therapy. The construction of drug delivery system based on QDs is a common method to investigate the therapy efficiency (Kuo, Chueh, Singh, Chien, & Chen, ; Rakovich & Rakovich, ; Su et al, ; Zhang et al, ). A typical approach is to employ surface‐functionalized QDs as drug carrier and tracer agent simultaneously.…”

Section: Biomedical Applications Of Quantum Dotsmentioning

confidence: 99%

Quantum dots from microfluidics for nanomedical application

Bian

Sun

Cai

et al. 2019

WIREs Nanomed Nanobiotechnol

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Nanomedicine, with its advantages of rapid diagnosis, high sensitivity and high accuracy, has aroused extensive interest of researchers, as the cornerstone of nanomedicine, nanomaterials achieve extra attention and rapid development.Among nanomaterials, quantum dots stand out due to their long fluorescence lifetime and excellent antiphotobleaching performance. At present, quantum dots have been applied to the diagnosis and treatment of diseases and various strategies have been presented to fabricate quantum dots. Microfluidic is one promising strategy since microfluidic device can provide an effective platform for the diagnosis of trace disease markers. In this paper, research progress in the microfluidic synthesis of quantum dots and quantum dot-based nanomedical application is discussed. The classification of quantum dots is firstly introduced, and the researches on quantum dots synthesis based on microfluidic is then mainly described, including the sort, design, preparation of microfluidic synthesis device and its application in synthesis.Nanomedical applications of the quantum dots is especially described and emphasized. The prospects for future development of quantum dots from microfluidic for nanomedical application are finally presented. This article is categorized under:Diagnostic Tools > in vitro Nanoparticle-Based Sensing K E Y W O R D S biomedical application, microfluidic, nanomedicine, quantum dot

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A graphene quantum dot@Fe 3 O 4 @SiO 2 based nanoprobe for drug delivery sensing and dual-modal fluorescence and MRI imaging in cancer cells

Cited by 146 publications

References 36 publications

Mechanisms of oxidative stress, apoptosis, and autophagy involved in graphene oxide nanomaterial anti-osteosarcoma effect

Mechanisms of oxidative stress, apoptosis, and autophagy involved in graphene oxide nanomaterial anti-osteosarcoma effect

Application of the Nano-Drug Delivery System in Treatment of Cardiovascular Diseases

Quantum dots from microfluidics for nanomedical application

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