A global perspective on the use, occurrence, fate and effects of anti-diabetic drug metformin in natural and engineered ecosystems

Briones, Rowena M.; Sarmah, Ajit K.; Padhye, Lokesh P.

doi:10.1016/j.envpol.2016.07.040

Cited by 115 publications

(56 citation statements)

References 49 publications

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“…Metformin is an antidiabetic drug that belongs to the family of biguanides, a group of drugs derived from the guanidine derivative Galega offininalis . Metformin is one of the most used drugs in the world for the treatment of patients with type 2 diabetes mellitus . It has a molecular weight of 129.1 g mol –1 , ionization (pKa) of 12.25 and an octanol–water partition coefficient (log K ow ) of −2.48 to −4.92, indicating that the drug is highly soluble in water and that higher amounts may be adsorbed on solids .…”

Section: Introductionmentioning

confidence: 99%

“…Trautwein and Kümmerer studied metformin removal in an aerobic suspended growth treatment process obtaining a removal of 51.3%. By using conventional treatment technologies (conventional activated sludge), a removal of metformin has been reported with a range of 59–98.6% . Santos et al carried out studies in a wastewater treatment plant for hospital sewage composed of four full‐scale trickling filters.…”

Section: Introductionmentioning

confidence: 99%

“…25 and an octanol-water partition coefficient (log K ow ) of −2.48 to −4.92, indicating that the drug is highly soluble in water and that higher amounts may be adsorbed on solids. 7,8 After oral administration of 500 mg metformin, 70% was recovered in urine and 30% in faeces. 9,10 Studies have shown that metformin has been detected in surface water at higher concentrations of 0.12-9.2 μg L -1 in the United States and 1-1.7 μg L -1 in Germany.…”

Section: Introductionmentioning

confidence: 99%

“…By using conventional treatment technologies (conventional activated sludge), a removal of metformin has been reported with a range of 59-98.6%. 7 Santos et al 22 carried out studies in a wastewater treatment plant for hospital sewage composed of four full-scale trickling filters. The obtained metformin and ciprofloxacin removal were in the range of 70-77%.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of a Ficus benjamina wood chip‐based aerated biofilter used for the removal of metformin and ciprofloxacin during domestic wastewater treatment

García‐Sánchez

Gutiérrez‐Macías

Estrada‐Arriaga

2019

J of Chemical Tech & Biotech

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BACKGROUND Several studies have demonstrated that the pharmaceuticals detected in the influents and effluents of wastewater treatment plants (WWTPs) can cause endocrine disruption and bacterial resistance on different species, in an aquatic environment. Metformin (antidiabetic drug) and ciprofloxacin (antibiotic quinolones) are compounds found at higher concentrations than many other pharmaceuticals, and thus have a disproportionately large environmental impact. This study is focused on the assessment of an aerated biofilter packed with Ficus benjamina wood chips for the simultaneous removal of metformin, ciprofloxacin, organic matter expressed as chemical oxygen demand (COD) and ammoniacal nitrogen (NH3‐N) during domestic wastewater treatment, under different superficial hydraulic loading. RESULTS The maximum removals of metformin, ciprofloxacin, COD and NH3‐N from the wastewater treated in an aerated biofilter were 94, 81, 91 and 38%, respectively, by applying a superficial hydraulic loading of 0.18 m3 m–2 d–1 [hydraulic retention time (HRT) of 7 h]. The adsorption capacity of F. benjamina wood chips on the metformin and ciprofloxacin was 0.1 and 2.03 µg gsupport material–1, respectively. CONCLUSION The maximum removal rates for metformin, ciprofloxacin, COD and NH3‐N were obtained when the aerated biofilter was operated at HRT = 7 h. The F. benjamina wood chips showed sorption properties of pharmaceuticals. According to a scanning electron microscopy image, the F. benjamina wood chips showed available pores in their entire surface, thus indicating that this organic support medium has a high potential for carrying out the sorption processes. Likewise, the surface of the wood chips showed the development of a homogeneous biofilm. © 2019 Society of Chemical Industry

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Assessment of a Ficus benjamina wood chip‐based aerated biofilter used for the removal of metformin and ciprofloxacin during domestic wastewater treatment

García‐Sánchez

Gutiérrez‐Macías

Estrada‐Arriaga

2019

J of Chemical Tech & Biotech

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“…However, there are other issues that need our attention too. Briones et al 14 extensively described the fate of metformin after it leaves our body and how it appears in wastewater and the environment. In this occasion, metformin may act as a real endocrine disruptor.…”

mentioning

confidence: 99%