A genomic cause of cerebral palsy should not change the clinical classification

Congenital Anomalies in Children With Cerebral Palsy: A Systematic Review

“…31 It is imperative that these children are retained under the clinical diagnosis of "cerebral palsy" (albeit with a known genetic cause), to avoid reporting a false decrease in the prevalence of cerebral palsy. 31,32 The use of strict, historical inclusion criteria for the definition of cerebral palsy will become increasingly important for epidemiologists working in this field. 33,34 Term birth was associated with congenital anomalies in children with cerebral palsy, [5][6][7] in particular, cerebral Syndromes/chromosomal anomalies included in "any congenital anomaly" category only.…”

“…However, there is an increasing trend to describe these cerebral palsy cases by their genetic diagnosis only. 31 It is imperative that these children are retained under the clinical diagnosis of “cerebral palsy” (albeit with a known genetic cause), to avoid reporting a false decrease in the prevalence of cerebral palsy. 31,32 The use of strict, historical inclusion criteria for the definition of cerebral palsy will become increasingly important for epidemiologists working in this field.…”

Congenital Anomalies in Children With Cerebral Palsy: A Systematic Review

“…31 It is imperative that these children are retained under the clinical diagnosis of "cerebral palsy" (albeit with a known genetic cause), to avoid reporting a false decrease in the prevalence of cerebral palsy. 31,32 The use of strict, historical inclusion criteria for the definition of cerebral palsy will become increasingly important for epidemiologists working in this field. 33,34 Term birth was associated with congenital anomalies in children with cerebral palsy, [5][6][7] in particular, cerebral Syndromes/chromosomal anomalies included in "any congenital anomaly" category only.…”

“…However, there is an increasing trend to describe these cerebral palsy cases by their genetic diagnosis only. 31 It is imperative that these children are retained under the clinical diagnosis of “cerebral palsy” (albeit with a known genetic cause), to avoid reporting a false decrease in the prevalence of cerebral palsy. 31,32 The use of strict, historical inclusion criteria for the definition of cerebral palsy will become increasingly important for epidemiologists working in this field.…”

All cases of cerebral palsy warrant genomic screening

“…It is important that a genetic causative finding should not change the clinical diagnosis of CP. 5 Although there will be counselling benefits in screening adults with CP, the main possible therapeutic benefits will be seen in young children and the younger the better. Neonatal screening may be an option in those with major risk factors for CP (e.g.…”

“…It is possible that whole genome sequencing will give the best diagnostic yield and in time RNA sequencing and epigenetic screening may add to the genetic diagnosis. It is important that a genetic causative finding should not change the clinical diagnosis of CP 5 …”

‘Outgrowing’ a cerebral palsy diagnosis

“…As MacLennan et al argue: ‘if one removes genetic causes or other causes of cerebral palsy…then in countries with cerebral palsy registers…there will be an artificial reduction in the incidence of this disorder…[I]n some countries the diagnosis of cerebral palsy allows access to financial benefits and social services…Removing genomic causes may disenfranchise these patients and families from the support they need. So, it is very helpful to keep the umbrella clinical diagnosis of cerebral palsy but have subclassifications by possible or likely cause’ …”

Congenital Anomalies in Children With Cerebral Palsy: A Systematic Review

“…31 It is imperative that these children are retained under the clinical diagnosis of "cerebral palsy" (albeit with a known genetic cause), to avoid reporting a false decrease in the prevalence of cerebral palsy. 31,32 The use of strict, historical inclusion criteria for the definition of cerebral palsy will become increasingly important for epidemiologists working in this field. 33,34 Term birth was associated with congenital anomalies in children with cerebral palsy, [5][6][7] in particular, cerebral Syndromes/chromosomal anomalies included in "any congenital anomaly" category only.…”

“…However, there is an increasing trend to describe these cerebral palsy cases by their genetic diagnosis only. 31 It is imperative that these children are retained under the clinical diagnosis of “cerebral palsy” (albeit with a known genetic cause), to avoid reporting a false decrease in the prevalence of cerebral palsy. 31,32 The use of strict, historical inclusion criteria for the definition of cerebral palsy will become increasingly important for epidemiologists working in this field.…”

All cases of cerebral palsy warrant genomic screening

“…It is important that a genetic causative finding should not change the clinical diagnosis of CP. 5 Although there will be counselling benefits in screening adults with CP, the main possible therapeutic benefits will be seen in young children and the younger the better. Neonatal screening may be an option in those with major risk factors for CP (e.g.…”

“…It is possible that whole genome sequencing will give the best diagnostic yield and in time RNA sequencing and epigenetic screening may add to the genetic diagnosis. It is important that a genetic causative finding should not change the clinical diagnosis of CP 5 …”

‘Outgrowing’ a cerebral palsy diagnosis

“…As MacLennan et al argue: ‘if one removes genetic causes or other causes of cerebral palsy…then in countries with cerebral palsy registers…there will be an artificial reduction in the incidence of this disorder…[I]n some countries the diagnosis of cerebral palsy allows access to financial benefits and social services…Removing genomic causes may disenfranchise these patients and families from the support they need. So, it is very helpful to keep the umbrella clinical diagnosis of cerebral palsy but have subclassifications by possible or likely cause’ …”

Congenital Anomalies in Children With Cerebral Palsy: A Systematic Review

“…31 It is imperative that these children are retained under the clinical diagnosis of "cerebral palsy" (albeit with a known genetic cause), to avoid reporting a false decrease in the prevalence of cerebral palsy. 31,32 The use of strict, historical inclusion criteria for the definition of cerebral palsy will become increasingly important for epidemiologists working in this field. 33,34 Term birth was associated with congenital anomalies in children with cerebral palsy, [5][6][7] in particular, cerebral Syndromes/chromosomal anomalies included in "any congenital anomaly" category only.…”

“…However, there is an increasing trend to describe these cerebral palsy cases by their genetic diagnosis only. 31 It is imperative that these children are retained under the clinical diagnosis of “cerebral palsy” (albeit with a known genetic cause), to avoid reporting a false decrease in the prevalence of cerebral palsy. 31,32 The use of strict, historical inclusion criteria for the definition of cerebral palsy will become increasingly important for epidemiologists working in this field.…”

All cases of cerebral palsy warrant genomic screening

“…It is important that a genetic causative finding should not change the clinical diagnosis of CP. 5 Although there will be counselling benefits in screening adults with CP, the main possible therapeutic benefits will be seen in young children and the younger the better. Neonatal screening may be an option in those with major risk factors for CP (e.g.…”

“…It is possible that whole genome sequencing will give the best diagnostic yield and in time RNA sequencing and epigenetic screening may add to the genetic diagnosis. It is important that a genetic causative finding should not change the clinical diagnosis of CP 5 …”

‘Outgrowing’ a cerebral palsy diagnosis

“…As MacLennan et al argue: ‘if one removes genetic causes or other causes of cerebral palsy…then in countries with cerebral palsy registers…there will be an artificial reduction in the incidence of this disorder…[I]n some countries the diagnosis of cerebral palsy allows access to financial benefits and social services…Removing genomic causes may disenfranchise these patients and families from the support they need. So, it is very helpful to keep the umbrella clinical diagnosis of cerebral palsy but have subclassifications by possible or likely cause’ …”