2012
DOI: 10.1038/ng.2247
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made to establish genetic influences on common early-onset obesity. We performed a North American-Australian-European collaborative meta-analysis of fourteen studies consisting of 5,530 cases (≥95th percentile of body mass index (BMI)) and 8,318 controls (<50th percentile of BMI) of European ancestry. Taking forward the eight novel signals yielding association with P < 5… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

8
167
1
2

Year Published

2013
2013
2022
2022

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 343 publications
(178 citation statements)
references
References 17 publications
8
167
1
2
Order By: Relevance
“…In addition, the participants in our studies were children aged 6-18 years. Compared with adults, it is reported that children have higher obesity heritability and usually have simple obesity without complications [12], which help to detect the effects of common variants on obesity. …”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…In addition, the participants in our studies were children aged 6-18 years. Compared with adults, it is reported that children have higher obesity heritability and usually have simple obesity without complications [12], which help to detect the effects of common variants on obesity. …”
Section: Discussionmentioning
confidence: 99%
“…The heritability of the variance ofBMI ranged from 30% to 70% [9], and it is estimated that heritability for BMI or obesity is higher in children than in adults [10]. In recent years, genome-wide association (GWA) studies have provided evidence for genetic risk loci for obesity [11,12,13,14]. Many replication studies for these loci have been conducted in multiple ethnic populations, including Chinese [15,16,17,18,19,20].…”
Section: Introductionmentioning
confidence: 99%
“…6,7 The largest study concerning the genetics of childhood obesity, where 5530 cases and 8318 controls were evaluated, showed a strong genetic influence in the development of childhood obesity. 8 The dopamine type-2 receptor (DRD2) gene contains 66.097 pb, it is located on chromosome 11 (q22-q23) and encodes the D2 subtype of the dopamine receptor, a transmembrane protein that couple to G-protein and inhibits adenylyl cyclase activity. This gene was included in HOGM (Human Obesity Gene Map) supported by 5 studies of candidate genes, but none of these studies had included children's evaluation.…”
Section: Introductionmentioning
confidence: 99%
“…Genome-wide association studies have led to the identification of several genetic variants, mainly single-nucleotide polymorphisms (SNPs), associated with obesity. Most studies have been performed in adult populations, although some obesity-related SNPs have also been assessed in children and adolescents, with either similar or discordant results compared to adult studies [7,8,9]. …”
Section: Introductionmentioning
confidence: 99%