A genome-scale screen identifies sulfated glycosaminoglycans as pivotal in epithelial cell damage byCandida albicans
Jianfeng Lin,
Jian Miao,
Katherine G. Schaefer
et al.
Abstract:Candidalysin is a cytolytic peptide produced by the opportunistic fungal pathogenCandida albicans. This peptide is a key virulence factor in mouse models of mucosal and hematogenously disseminated candidiasis. Despite intense interest in the role of candidalysin inC. albicanspathogenicity, its host cell targets have remained elusive. To fill this knowledge gap, we performed a genome-wide loss-of-function CRISPR screen in a human oral epithelial cell line to identify specific host factors required for susceptib… Show more
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