A Genetically Informed Study of the Association Between Childhood Separation Anxiety, Sensitivity to CO2, Panic Disorder, and the Effect of Childhood Parental Loss

Battaglia, Marco; Pesenti‐Gritti, Paola; Medland, Sarah E.; Ogliari, Anna; Tambs, Kristian; Spatola, Chiara A. M.

doi:10.1001/archgenpsychiatry.2008.513

Cited by 109 publications

(98 citation statements)

References 52 publications

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“…Best-fit solutions from all three computational approaches, however, correspond in suggesting a role for shared environmental factors in affecting the risk for Anxiety and Affective Problems in children aged 8-11 years, consistently with recent epidemiological-, quantitative genetic-, and molecular genetic studies [4,14,33]. Clinicians may therefore pay special attention in assessing the presence of environmental risk/precipitating factors in children who are referred for these disorders.…”

Section: Resultssupporting

confidence: 57%

Genetic and environmental influences upon the CBCL/6-18 DSM-oriented scales: similarities and differences across three different computational approaches and two age ranges

Spatola

Rende

Battaglia

2010

Eur Child Adolesc Psychiatry

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To cite this version:Chiara A. M. Spatola, Richard Rende, Marco Battaglia. Genetic and environmental influences upon the CBCL/6-18 DSM-oriented scales: similarities and differences across three different computational approaches and two age ranges. European child & adolescent psychiatry, 2010, 19 (8), pp.647-658. <10.1007/s00787-010-0102-z>. ORIGINAL CONTRIBUTIONGenetic and environmental influences upon the CBCL/6-18 DSM-oriented scales: similarities and differences across three different computational approaches and two age ranges Abstract Inasmuch as the newly established DSM-oriented CBCL/6-18 scales are to be increasingly employed to assess clinical/high-risk populations, it becomes important to explore their aetiology both within the normal-and the extreme range of variation in general population samples and to compare the results obtained in different age groups. We investigated by the Quantitative Maximum Likelihood, the De Fries-Fulker, and the Ordinal Maximum Likelihood methods the genetic and environmental influences upon the five DSM-oriented CBCL/6-18 scales in 796 twins aged 8-17 years belonging to the general population-based Italian Twin Registry. When children were analysed together regardless of age, most best-fitting solutions yielded genetic and non-shared environmental factors as the sole influences for DSMoriented CBCL/6-18 behaviours, both for the normal and the extreme variations. When analyses were conducted separately for two age groups, shared environmental influences emerged consistently for Affective and Anxiety Problems in children aged 8-11. Oppositional-Defiant, Attention Deficit/Hyperactivity, and Conduct Problems appeared-with few exceptions-influenced only by genetic and non-shared environmental factors in both age groups, according to all three computational approaches. The De Fries-Fulker method appeared to be more sensitive in detecting shared environmental effects. Analysing the same set of data with different analytic approaches leads to better-balanced views on the aetiology of psychopathological behaviours in the developmental years.

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Section: Resultssupporting

confidence: 57%

Genetic and environmental influences upon the CBCL/6-18 DSM-oriented scales: similarities and differences across three different computational approaches and two age ranges

Spatola

Rende

Battaglia

2010

Eur Child Adolesc Psychiatry

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“…Battaglia et al reported three experiments [86][87][88] in which another variable was added to the twins' equation: the occurrence of traumatic events such as those leading to childhood separation anxiety, death of parents, and a history of generally stressful situations in childhood. The first of these, 86 with 700 twins, suggested the existence of a continuum of childhood separation anxiety and PD, and the association of both disorders with hypersensitivity to CO 2 .…”

Section: Twin Studiesmentioning

confidence: 99%

“…The first of these, 86 with 700 twins, suggested the existence of a continuum of childhood separation anxiety and PD, and the association of both disorders with hypersensitivity to CO 2 .…”

Section: Twin Studiesmentioning

confidence: 99%

The carbon dioxide challenge test in panic disorder: a systematic review of preclinical and clinical research

Amaral

Spadaro

Pereira³

et al. 2013

Rev. Bras. Psiquiatr.

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This systematic review assesses the current state of clinical and preclinical research on panic disorder (PD) in which the carbon dioxide (CO 2 ) challenge was used as a trigger for panic attacks (PAs). A total of 95 articles published from 1984 to 2012 were selected for inclusion. Some hypotheses for PD evolved greatly due to the reproducibility of PAs in a controlled environment using the safe and noninvasive CO 2 test. The 35% CO 2 protocol was the method chosen by the majority of studies. Results of the test report specific sensitivity to hypercapnia in PD patients of the respiratory PD subtype. The CO 2 challenge helped assess the antipanic effects of medication and nonpharmaceutical approaches such as physical exercise and cognitive behavioral therapy. The test was also used in studies about the genetic component of PD, in which twins and relatives of PD patients were analyzed.

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“…Early-life experiences may have long-term consequences (42)(43)(44)(45)(46) and have been associated to functional and morphological abnormalities in brain regions connected with emotionality such as the amygdala, the hippocampus, and the prefrontal cortex (47,48).…”

Section: Models Of Environmental Manipulationmentioning

confidence: 99%

“…Human studies show that SAD predicts heightened risk to develop PD in adulthood (75,76) and both these conditions are associated with heightened sensitivity to CO 2 (44,77,78). In turn, CO 2 hypersensitivity shares common genetic determinants with both SAD and PD, with childhood parental loss adding a significant contribution to explain covariation (44).…”

Section: Endophenotype Levelmentioning

confidence: 99%

Animal Models of Human Anxiety Disorders: Reappraisal From a Developmental Psychopathology Vantage Point

2011

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ABSTRACT:We are witnessing a tremendous expansion of strategies and techniques that derive from basic and preclinical science to study the fine genetic, epigenetic, and proteomic regulation of behavior in the laboratory animal. In this endeavor, animal models of psychiatric illness are becoming the almost exclusive domain of basic researchers, with lesser involvement of clinician researchers in their conceptual design, and transfer into practice of new paradigms. From the side of human behavioral research, the growing interest in gene-environment interplay and the fostering of valid endophenotypes are among the few substantial innovations in the effort of linking common mental disorders to cutting-edge clinical research questions. We argue that it is time for cross-fertilization between these camps. In this article, we a) observe that the "translational divide" can-and should-be crossed by having investigators from both the basic and the clinical sides cowork on simpler, valid "endophenotypes" of neurodevelopmental relevance; b) emphasize the importance of unambiguous physiological readouts, more than behavioral equivalents of human symptoms/syndromes, for animal research; c) indicate and discuss how this could be fostered and implemented in a developmental framework of reference for some common anxiety disorders and ultimately lead to better animal models of human mental disorders. (Pediatr Res 69: 77R-84R, 2011)

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A Genetically Informed Study of the Association Between Childhood Separation Anxiety, Sensitivity to CO2, Panic Disorder, and the Effect of Childhood Parental Loss

Cited by 109 publications

References 52 publications

Genetic and environmental influences upon the CBCL/6-18 DSM-oriented scales: similarities and differences across three different computational approaches and two age ranges

Genetic and environmental influences upon the CBCL/6-18 DSM-oriented scales: similarities and differences across three different computational approaches and two age ranges

The carbon dioxide challenge test in panic disorder: a systematic review of preclinical and clinical research

Animal Models of Human Anxiety Disorders: Reappraisal From a Developmental Psychopathology Vantage Point

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