Journal of Chromatography A 2012 DOI: 10.1016/j.chroma.2011.12.018 View full text
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Steffen Wiese, Thorsten Teutenberg, Torsten C. Schmidt

Abstract: In the present work it is shown that the linear elution strength (LES) model which was adapted from temperature-programming gas chromatography (GC) can also be employed for systematic method development in high-temperature liquid chromatography (HT-HPLC). The ability to predict isothermal retention times based on temperature-gradient as well as isothermal input data was investigated. For a small temperature interval of ΔT=40°C, both approaches result in very similar predictions. Average relative errors of pred…

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